TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.
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PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.
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DNA hypermethylation in lung cancer is targeted at differentiation-associated genes.
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Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers.
Restoration of liver mass after injury requires proliferative and not embryonic transcriptional patterns.
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