Miller, Miles , PhD
Miles Miller received his A.B. in Chemistry from Princeton University, and his Ph.D. in Biological Engineering from the Massachusetts Institute of Technology (Advisors: Douglas Lauffenburger and Linda Griffith). He trained as a NIH postdoctoral fellow under Dr. Ralph Weissleder at MGH. He specializes in parsing mechanisms of cell signaling and drug action from a quantitative network-level perspective, with training in computational modeling, imaging, nanotechnology, cell signaling biology, and drug delivery.
Selected Publications (from total of 48)
Development and Application of the Metalloprotease Activity Multi-plexed Bead-based Immunoassay (MAMBI).
Single‐Cell Intravital Microscopy of Trastuzumab Quantifies Heterogeneous in vivo Kinetics
Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation.
Quantitative Imaging of Tumor Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin.
Site occupancy calibration of taxane pharmacology in live cells and tissues
Ultrafast Single-Cell Level Enzymatic Tumor Profiling.
ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker.
Gold photothermal therapy: A positive for negative margins
Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease
It’s what’s inside that counts for nanoparticle vaccines
Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates.
Less is more for anticancer therapy combinations
Nanotransfection brings progress that’s more than skin-deep
Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior
Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis.