Jason McCarthy's Group

My laboratory focuses upon the synthesis and application of nanomaterials in the imaging and therapy of disease. In particular, we are interested in the utility of these nanoagents in cardiovascular disease and its sequelae. Nanotechnology plays an increasing role in molecular diagnostics, in vivo imaging, and improved treatment of disease. The usefulness of nanoparticles is mainly derived from their small size, large surface area, and kinetics for in vivo drug delivery. The ability to functionalize the surface with targeting ligands, as well as imaging and therapeutic moieties also allows for the creation of multimodal, multifunctional nanoagents. The laboratory is part of the Chemical Biology Platform and the Nanotechnology Program at CSB, and collaborates with multidisciplinary groups across the Harvard Medical School community in order to focus upon clinically translatable strategies to fill unmet needs in disease detection and treatment.

Recent Publications (more...)

McCarthy JR
Book review: the handbook of nanomedicine (2nd edition).
Nanomedicine (Lond). 2013;8(2):173-5 - PMID: 23394153
Saxena A, Kessinger CW, Thompson B, McCarthy JR, Iwamoto Y, Lin CP, Jaffer FA
High-Resolution Optical Mapping of Inflammatory Macrophages Following Endovascular Arterial Injury.
Mol Imaging Biol. 2012;15(3):282-9 - PMID: 23090852 - PMCID: PMC3650124
Ripplinger CM, Kessinger CW, Li C, Kim JW, McCarthy JR, Weissleder R, Henke PK, Lin CP, Jaffer FA
Inflammation Modulates Murine Venous Thrombosis Resolution In Vivo: Assessment by Multimodal Fluorescence Molecular Imaging.
Arterioscler Thromb Vasc Biol. 2012;32(11):2616-24 - PMID: 22995524 - PMCID: PMC3516622
Brueckner C, Ogikubo J, McCarthy JR, Akhigbe J, Hyland MA, Daddario P, Worlinsky JL, Zeller M, Engle JT, Ziegler CJ, Ranaghan MJ, Sandberg MN, Birge RR
meso-Arylporpholactones and their Reduction Products.
J Org Chem. 2012;77(15):6480-94 - PMID: 22734444 - PMCID: PMC3411881

Jason McCarthy