Investigator

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Paunescu, Teodor, PhD

Teodor_paunescu
Phone: 617-726-3696
Email: Paunescu.Teodor@mgh.harvard.edu
Lab: Brown, Dennis

Research

Our research focuses on the vacuolar proton-pumping ATPase (V-ATPase), and in particular on the role of its B subunit isoforms in the physiology and pathophysiology of H+ secretion. The V-ATPase plays an essential role in numerous membrane trafficking processes by mediating the acidification of intracellular organelles. When expressed in the plasma membrane domain, the V-ATPase mediates active H+ transport into, and the pH regulation of, extracellular compartments. The V-ATPase 56 kDa B subunit occurs in mammalian tissues as two homologous isoforms, Atp6v1b1, or B1 (highly expressed in a restricted number of epithelia specialized for regulated H+ transport, including the urogenital tract, the inner ear, eye, respiratory and olfactory epithelia), and the ubiquitous Atp6v1b2 (B2) isoform.

Publications

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Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA
Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq.
Proc Natl Acad Sci U S A. 2017;114(46):E9989-E9998 - PMID: 29089413
Nigwekar SU, Weiser JM, Kalim S, Xu D, Wibecan JL, Dougherty SM, Mercier-Lafond L, Corapi KM, Eneanya ND, Holbrook EH, Brown D, Thadhani RI, Păunescu TG
Characterization and Correction of Olfactory Deficits in Kidney Disease.
J Am Soc Nephrol. 2017;28(11):3395-3403 - PMID: 28775001 - PMCID: PMC5661283
Li W, Jin WW, Tsuji K, Chen Y, Nomura N, Su L, Yui N, Arthur J, Cotecchia S, Păunescu TG, Brown D, Lu HAJ
Direct interaction of ezrin and AQP2 and its role in AQP2 trafficking.
J Cell Sci. 2017;130(17):2914-2925 - PMID: 28754689
Mamuya FA, Xie D, Lei L, Huang M, Tsuji K, Capen DE, Yang B, Weissleder R, Păunescu TG, Lu HJ
Deletion of β-1 integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.
Am J Physiol Renal Physiol. 2017;:ajprenal.00038.2017 - PMID: 28701310 - PMCID: PMC5668581
Christensen HL, Păunescu TG, Matchkov V, Barbuskaite D, Brown D, Damkier HH, Praetorius J
The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations.
Physiol Rep. 2017;5(1):ePub - PMID: 28053225 - PMCID: PMC5256157
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