Investigator

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Paunescu, Teodor, PhD

Teodor_paunescu
Phone: 617-726-3696
Email: Paunescu.Teodor@mgh.harvard.edu
Lab: Brown, Dennis

Research

Our research focuses on the vacuolar proton-pumping ATPase (V-ATPase), and in particular on the role of its B subunit isoforms in the physiology and pathophysiology of H+ secretion. The V-ATPase plays an essential role in numerous membrane trafficking processes by mediating the acidification of intracellular organelles. When expressed in the plasma membrane domain, the V-ATPase mediates active H+ transport into, and the pH regulation of, extracellular compartments. The V-ATPase 56 kDa B subunit occurs in mammalian tissues as two homologous isoforms, Atp6v1b1, or B1 (highly expressed in a restricted number of epithelia specialized for regulated H+ transport, including the urogenital tract, the inner ear, eye, respiratory and olfactory epithelia), and the ubiquitous Atp6v1b2 (B2) isoform.

Publications

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Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, P─âunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA
Reply to Edemir: Physiological regulation and single-cell RNA sequencing.
Proc Natl Acad Sci U S A. 2018;115(3):E351-E352 - PMID: 29311339 - DOI: 10.1073/pnas.1720333115
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