Mazitschek, Ralph, PhD

Phone: 617-643-6286
Lab: Mazitschek, Ralph


Dr. Mazitschek is an Assistant Professor at Harvard Medical School and Co-Director of the Chemical Biology Platform at the Center for Systems Biology at Massachusetts General Hospital (MGH). Dr. Mazitschek is also a member of the Infectious Diseases Initiative at The Broad Institute of Harvard and MIT, associate Faculty at the Center for Human Genetic Research at MGH and Visiting Scientist at the Department of Immunology and Infectious Diseases at Harvard School of Public Health.

Dr. Mazitschek graduated from the University of Leipzig in 2002 with a Ph.D. in Organic Chemistry. He continued hist research at the Institute of Chemistry and Cell Biology (ICCB) at Harvard Medical School first as postdoc and later as Institute Fellow, from which he joined the Chemical Biology Program at the newly founded Broad Institute of Harvard and MIT. In 2008 he joined the faculty of the Center for Systems Biology at the Massachusetts General Hospital to continue his independent research.


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Reis SA, Ghosh B, Hendricks JA, Szantai-Kis DM, Törk L, Ross KN, Lamb J, Read-Button W, Zheng B, Wang H, Salthouse C, Haggarty SJ, Mazitschek R
Light-controlled modulation of gene expression by chemical optoepigenetic probes.
Nat Chem Biol. 2016;12(5):317-323 - PMID: 26974814 - PMCID: PMC4836974
Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, Wirth DF, André V, Duarte MT, Guedes RC, J V A Dos Santos D, Rosenthal PJ, Mazitschek R, Prudêncio M, Moreira R
Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites.
ChemMedChem. 2016;11(19):2194-2204 - PMID: 27538856
Ghosh B, Zhao WN, Reis SA, Patnaik D, Fass DM, Tsai LH, Mazitschek R, Haggarty SJ
Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.
Bioorg Med Chem Lett. 2016;26(4):1265-71 - PMID: 26804233 - PMCID: PMC4753070