Lu, Jenny (Hua), MD, PhD

Assistant Professor

Phone: 617-724-9815
Email: Lu.Hua@mgh.harvard.edu
Lab: Lu, Jenny (Hua)

Publications

  • Cheung PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Lu HA, Brown D, Bouley R EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption. J Am Soc Nephrol. 2016;27(10):3105-3116 - PMID: 27694161 - PMCID: PMC5042667 - DOI: 10.1681/ASN.2015080903

  • Cheung PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Jenny Lu HA, Brown D, Bouley R EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption. J Am Soc Nephrol. 2016;:ePub - PMID: 26961350 - DOI: 10.1681/ASN.2015080903

  • Rice WL, Li W, Mamuya F, McKee M, P─âunescu TG, Lu HA Polarized Trafficking of AQP2 Revealed in Three Dimensional Epithelial Culture. PLoS ONE. 2015;10(7):e0131719 - PMID: 26147297 - PMCID: PMC4493001 - DOI: 10.1371/journal.pone.0131719

  • Arthur J, Huang J, Nomura N, Jin WW, Li W, Cheng X, Brown D, Lu HJ Characterization of the putative phosphorylation sites of the AQP2 c-terminus and their role in AQP2 trafficking in LLC-PK1 cells. Am J Physiol Renal Physiol. 2015;:ajprenal.00152.2015 - PMID: 26290367 - PMCID: PMC4609919 - DOI: 10.1152/ajprenal.00152.2015

  • Nomura N, Nunes P, Bouley R, Nair AV, Shaw S, Ueda E, Pathomthongtaweechai N, Lu HA, Brown D High throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration. Am J Physiol Cell Physiol. 2014;307(7):C597-605 - PMID: 24944200 - PMCID: PMC4187055 - DOI: 10.1152/ajpcell.00154.2014

  • Huang J, McKee M, Huang HD, Xiang A, Davidson AJ, Lu HA A zebrafish model of conditional targeted podocyte ablation and regeneration. Kidney Int. 2013;83(6):1193-200 - PMID: 23466998 - PMCID: PMC3672345 - DOI: 10.1038/ki.2013.6

  • Paunescu TG, Lu HA, Russo LM, Pastor-Soler NM, McKee M, McLaughlin MM, Bartlett BE, Breton S, Brown D Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells. Am J Physiol Renal Physiol. 2013;305(12):F1783-F1795 - PMID: 24133120 - PMCID: PMC3882446 - DOI: 10.1152/ajprenal.00622.2012

  • Brown D, Jenny Lu HA Aquaporin-2 Inhibitors: Fishing in the Chemical Pool. J Am Soc Nephrol. 2013;24(5):685-6 - PMID: 23599384 - DOI: 10.1681/ASN.2013030243

  • Yui N, Lu HA, Chen Y, Nomura N, Bouley R, Brown D Basolateral targeting and microtubule dependent transcytosis of the aquaporin-2 water channel. Am J Physiol Cell Physiol. 2013;304(1):C38-48 - PMID: 23015545 - PMCID: PMC3543574 - DOI: 10.1152/ajpcell.00109.2012

  • Yui N, Lu HJ, Bouley R, Brown D AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells. Biol Open. 2012;1(2):101-8 - PMID: 23213402 - PMCID: PMC3507199 - DOI: 10.1242/bio.2011042

  • Chen Y, Rice W, Gu Z, Li J, Huang J, Brenner MB, Van Hoek A, Xiong J, Gundersen GG, Norman JC, Hsu VW, Fenton RA, Brown D, Lu HA Aquaporin 2 Promotes Cell Migration and Epithelial Morphogenesis. J Am Soc Nephrol. 2012;23(9):1506-17 - PMID: 22859853 - PMCID: PMC3431417 - DOI: 10.1681/ASN.2012010079

  • Brown D, Bouley R, Paunescu TG, Breton S, Lu HA New insights into the dynamic regulation of water and acid/base balance by renal epithelial cells. Am J Physiol Cell Physiol. 2012;302(10):C1421-33 - PMID: 22460710 - PMCID: PMC3362000 - DOI: 10.1152/ajpcell.00085.2012

  • Rice WL, Zhang Y, Chen Y, Matsuzaki T, Brown D, Lu HA Differential, Phosphorylation Dependent Trafficking of AQP2 in LLC-PK1 Cells. PLoS ONE. 2012;7(2):e32843 - PMID: 22403603 - PMCID: PMC3293519 - DOI: 10.1371/journal.pone.0032843

  • Li W, Zhang Y, Bouley R, Chen Y, Matsuzaki T, Nunes P, Hasler U, Brown D, Lu HA Simvastatin Enhances Aquaporin 2 Surface Expression and Urinary Concentration in Vasopressin Deficient Brattleboro Rats through Modulation of Rho GTPase. Am J Physiol Renal Physiol. 2011;301(2):F309-18 - PMID: 21511701 - PMCID: PMC3154588 - DOI: 10.1152/ajprenal.00001.2011

  • Bouley R, Lu HA, Nunes P, Da Silva N, McLaughlin M, Chen Y, Brown D Calcitonin Has a Vasopressin-like Effect on Aquaporin-2 Trafficking and Urinary Concentration. J Am Soc Nephrol. 2011;22(1):59-72 - PMID: 21071524 - PMCID: PMC3014035 - DOI: 10.1681/ASN.2009121267

  • Bouley R, Palomino Z, Tang SS, Nunes P, Kobori H, Lu HA, Shum WW, Sabolic I, Brown D, Ingelfinger JR, Jung FF Angiotensin II and Hypertonicity Modulate Proximal Tubular Aquaporin 1 (AQP1) Expression. Am J Physiol Renal Physiol. 2009;297(6):F1575-86 - PMID: 19776169 - PMCID: PMC2801332 - DOI: 10.1152/ajprenal.90762.2008

  • Van Hoek AN, Bouley R, Lu YX, Silberstein CM, Brown D, Wax MB, Patil RV Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arrays. Am J Physiol Renal Physiol. 2009;296(6):F1396-404 - PMID: 19297454 - PMCID: PMC2692439 - DOI: 10.1152/ajprenal.00018.2009

  • Nunes P, Hasler U, McKee M, Lu HA, Bouley R, Brown D A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2 (AQP2). Am J Physiol Cell Physiol. 2008;295(6):C1476-87 - PMID: 18799651 - PMCID: PMC2603565 - DOI: 10.1152/ajpcell.00344.2008

  • Brown D, Hasler U, Nunes P, Bouley R, Lu H Phosphorylation events and the modulation of aquaporin 2 cell surface expression. Curr Opin Nephrol Hypertens. 2008;17(5):491-8 - PMID: 18695390 - PMCID: PMC3774073 - DOI: 10.1097/MNH.0b013e3283094eb1

  • Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D Acute hypertonicity alters aquaporin-2 trafficking and induces a MAP kinase-dependent accumulation at the plasma membrane of renal epithelial cells. J Biol Chem. 2008;283(39):26643-61 - PMID: 18664568 - PMCID: PMC2546545 - DOI: 10.1074/jbc.M801071200

  • Bouley R, Hasler U, Lu HA, Nunes P, Brown D Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus. Semin Nephrol. 2008;28:266-78 - PMID: 18519087 - PMCID: PMC2494582 - DOI: 10.1016/j.semnephrol.2008.03.010

  • Lu HA, Matsuzaki T, Bouley R, Hasler U, Qin Q, Brown D The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells. Am J Physiol Renal Physiol. 2008;295(1):F290-4 - PMID: 18434387 - PMCID: PMC2494506 - DOI: 10.1152/ajprenal.00072.2008

  • Paunescu TG, Da Silva N, Russo LM, McKee M, Lu HA, Breton S, Brown D Association Of Soluble Adenylyl Cyclase (sAC) With The V-ATPase In Renal Epithelial Cells. Am J Physiol Renal Physiol. 2008;294(1):F130-8 - PMID: 17959750 - DOI: 10.1152/ajprenal.00406.2007

  • Lu HA, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D Heat shock protein 70 interacts with aquaporin-2 (AQP2) and regulates its trafficking. J Biol Chem. 2007;282(39):28721-32 - PMID: 17636261 - DOI: 10.1074/jbc.M611101200

  • Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DA Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R. Am J Physiol Renal Physiol. 2007;292(5):F1303-13 - PMID: 17287200 - DOI: 10.1152/ajprenal.00441.2005