Vinegoni, Claudio, PhD

Assistant Professor

In vivo Microscopy Core

Phone: (617) 643-6137
Email: cvinegoni@mgh.harvard.edu
Lab: Weissleder, Ralph

The current research activity involves the development of novel optical mesoscopic molecular imaging techniques that allow to generate in-vivo three-dimensional data in optically diffusive non-transparent living organisms with a size up to a few millimeters (e.g. Drosophila Melanogaster, Zebrafish) providing both in-vivo anatomical and functional imaging.

At the same time we are committed into the development of new fluorescence molecular tomography (FMT) techniques in diffusive regime for whole mouse imaging. Other research activities involve in vivo near infrared fluorescence imaging of protease activity in rabbit models of atherosclerosis and the development of novel fiber based imaging systems, and the development of combined optical and opto-acoustic multispectral tomographic imaging for in-vivo imaging applications.

Other macro and mesoscopic imaging technique are pursued such as Born normalized Optical Projection Tomography with molecular contrast for ex-vivo small animal and whole organ imaging. This technique provides detailed tomographic reconstruction of morphology and molecular probes within tissue with resolution up to 5 microns in entire organs (e.g. heart, brain, kidney, etc) and can complement in-vivo imaging techniques such as FMT and MPM.

We are developing new applications for novel microscopy imaging systems and design and conduct cutting-edge experiments. In particular we are interested in providing new techniques for motion compensation for multiphoton microscopy in order to avoid artifacts due to respiratory and cardiac motion. Both hardware and software based approaches are conducted.

Publications

  • Grune J, Bajpai G, Ocak PT, Kaufmann E, Mentkowksi K, Pabel S, Kumowski N, Pulous FE, Tran KA, Rohde D, Zhang S, Iwamoto Y, Wojtkiewicz GR, Vinegoni C, Green U, Swirski FK, Stone JR, Lennerz JK, Divangahi M, Hulsmans M, Nahrendorf M Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart. Circulation. 2024;:ePub - PMID: 38506045 - DOI: 10.1161/CIRCULATIONAHA.123.066433

  • Hulsmans M, Schloss MJ, Lee IH, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous FE, Keller D, Bening C, Green U, Lennerz JK, Mitchell RN, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong CS, Pierson RN, Aster JC, Rohde D, Wojtkiewicz GR, Weissleder R, Swirski FK, Tellides G, Tolis G, Melnitchouk S, Milan DJ, Ellinor PT, Naxerova K, Nahrendorf M Recruited macrophages elicit atrial fibrillation. Science. 2023;381(6654):231-239 - PMID: 37440641 - PMCID: PMC10448807 - DOI: 10.1126/science.abq3061

  • Grune J, Lewis AJM, Yamazoe M, Hulsmans M, Rohde D, Xiao L, Zhang S, Ott C, Calcagno DM, Zhou Y, Timm K, Shanmuganathan M, Pulous FE, Schloss MJ, Foy BH, Capen D, Vinegoni C, Wojtkiewicz GR, Iwamoto I, Grune T, Brown D, Higgins J, Ferreira VM, Herring N, Channon KM, Neubauer S, Oxford Acute Myocardial Infarction (OxAMI) Study, Sosnovik DE, Milan DJ, Swirski FK, King KR, Aguirre AD, Ellinor PT, Nahrendorf M Neutrophils incite and macrophages avert electrical storm after myocardial infarction. Nat Cardiovasc Res. 2022;1(7):649-664 - PMID: 36034743 - PMCID: PMC9410341 - DOI: 10.1038/s44161-022-00094-w

  • Ko J, Wilkovitsch M, Oh J, Kohler RH, Bolli E, Pittet MJ, Vinegoni C, Sykes DB, Mikula H, Weissleder R, Carlson JCT Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes. Nat Biotechnol. 2022;40(11):1654-1662 - PMID: 35654978 - PMCID: PMC9669087 - DOI: 10.1038/s41587-022-01339-6

  • Pulous FE, Cruz-Hernandez JC, Yang C, Kaya Z, Paccalet A, Wojtkiewicz G, Capen D, Brown D, Wu JW, Schloss MJ, Vinegoni C, Richter D, Yamazoe M, Hulsmans M, Momin N, Grune J, Rohde D, McAlpine CS, Panizzi P, Weissleder R, Kim DE, Swirski FK, Lin CP, Moskowitz MA, Nahrendorf M Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis. Nat Neurosci. 2022;25(5):567-576 - PMID: 35501382 - PMCID: PMC9081225 - DOI: 10.1038/s41593-022-01060-2

  • Rohde D, Vandoorne K, Lee IH, Grune J, Zhang S, McAlpine CS, Schloss MJ, Nayar R, Courties G, Frodermann F, Wojtkiewicz G, Honold L, Chen Q, Schmidt S, Iwamoto Y, Sun Y, Cremer S, Hoyer FF, Iborra-Egea O, Muñoz-Guijosa C, Fei Ji F, Zhou B, Adams RH, Wythe JD, Hidalgo J, Watanabe H, Jung Y, van der Laan AM, Piek JJ, Kfoury Y, Désogère PA, Vinegoni C, Dutta P, Sadreyev RI, Caravan P, Bayes-Genis A, Libby P, Scadden DT, Lin CP Naxerova K, Swirski FK, Nahrendorf M Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease. Nat Cardiovasc Res. 2022;1:28–44 - PMID: 35747128 - PMCID: PMC9216333 - DOI: 10.1038/s44161-021-00002-8

  • McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease. Nature. 2021;595(7869):701-706 - PMID: 34262178 - PMCID: PMC8934148 - DOI: 10.1038/s41586-021-03734-6

  • Fumene Feruglio P, Vinegoni C, Weissleder R Extended dynamic range imaging for noise mitigation in fluorescence anisotropy imaging. J Biomed Opt. 2020;25(8):ePub - PMID: 32820624 - PMCID: PMC7439791 - DOI: 10.1117/1.JBO.25.8.086003

  • Bachar Issa TH, Vinegoni C, Shaw A, Fumene Feruglio P, Weissleder R, Uminsky D Video-Rate Acquisition Fluorescence Microscopy via Generative Adversarial Networks. EasyChair. 2020;:ePub

  • Min J*, Chin LK*, Oh J, Landeros C, Vinegoni C, Lee J, Lee SJ, Park JY, Liu AQ, Castro CM, Lee H, Im H, Weissleder R CytoPAN—Portable cellular analyses for rapid point-of-care cancer diagnosis. Sci Transl Med. 2020;12:eaaz9746 - PMID: 32759277 - PMCID: PMC8217912 - DOI: 10.1126/scitranslmed.aaz9746

  • Vinegoni C, Fumene Feruglio P, Courties G, Schmidt S, Hulsmans M, Lee S, Wang R, Sosnovik D, Nahrendorf M, Weissleder R Fluorescence microscopy tensor imaging representations for large-scale dataset analysis. Sci Rep. 2020;10(1):5632 - PMID: 32221334 - PMCID: PMC7101442 - DOI: 10.1038/s41598-020-62233-2

  • Cremer S, Schloss MJ, Vinegoni C, Foy BH, Zhang S, Rohde D, Hulsmans M, Fumene Feruglio P, Schmidt S, Wojtkiewicz G, Higgins JM, Weissleder R, Swirski FK, Nahrendorf M Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction. J Am Coll Cardiol. 2020;75(8):901-915 - PMID: 32130926 - PMCID: PMC7254576 - DOI: 10.1016/j.jacc.2019.12.056

  • Fraser K, Jo A, Giedt J, Vinegoni C, Yang KS, Peruzzi P, Chiocca EA, Breakefield XO, Lee H, Weissleder R Characterization of single microvesicles in plasma from glioblastoma patients. Neuro Oncol. 2019;21(5):606-615 - PMID: 30561734 - PMCID: PMC6502493 - DOI: 10.1093/neuonc/noy187

  • Vinegoni C, Feruglio PF, Weissleder R High dynamic range fluorescence imaging. IEEE J Sel Top Quantum Electron. 2018;25(1):ePub - PMID: 31598059 - PMCID: PMC6785194 - DOI: 10.1109/JSTQE.2018.2881608

  • Vinegoni C, Feruglio PF, Weissleder R High dynamic range fluorescence imaging. IEEE J Sel Top Quantum Electron. 2018;25(1):ePub - PMID: 31598059 - PMCID: PMC6785194 - DOI: 10.1109/JSTQE.2018.2881608

  • Vasaturo M, Cotugno R, Fiengo L, Vinegoni C, Dal Piaz F, De Tommasi N The anti-tumor diterpene oridonin is a direct inhibitor of Nucleolin in cancer cells. Sci Rep. 2018;8(1):16735 - PMID: 30425290 - PMCID: PMC6233161 - DOI: 10.1038/s41598-018-35088-x

  • Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Santos Masson G, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration. Nat Neurosci. 2018;21(9):1209-1217 - PMID: 30150661 - PMCID: PMC6148759 - DOI: 10.1038/s41593-018-0213-2

  • Vandoorne K, Rohde D, Kim HY, Courties G, Wojtkiewicz GR, Honold L, Hoyer FF, Frodermann V, Nayar R, Herisson FE, Jung Y, Désogère P, Vinegoni C, Caravan P, Weissleder R, Sosnovik DE, Lin CP, Swirski FK, Nahrendorf M Imaging the Vascular Bone Marrow Niche During Inflammatory Stress. Circ Res. 2018;123(4):415-427 - PMID: 29980569 - PMCID: PMC6202141 - DOI: 10.1161/CIRCRESAHA.118.313302

  • Vinegoni C, Feruglio PF, Gryczynski I, Mazitschek R, Weissleder R Fluorescence anisotropy imaging in drug discovery. Adv Drug Deliv Rev. 2018;151-152:262-288 - PMID: 29410158 - PMCID: PMC6072632 - DOI: 10.1016/j.addr.2018.01.019

  • Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018;215(2):423-440 - PMID: 29339450 - PMCID: PMC5789416 - DOI: 10.1084/jem.20171274

  • Vinegoni C, Fumene Feruglio P, Brand C, Lee S, Nibbs AE, Stapleton S, Shah S, Gryczynski I, Reiner T, Mazitschek R, Weissleder R Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging. Nat Protoc. 2017;12(7):1472-1497 - PMID: 28686582 - PMCID: PMC5928516 - DOI: 10.1038/nprot.2017.043

  • Mikula H, Stapleton S, Kohler RH, Vinegoni C, Weissleder R Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging. Theranostics. 2017;7(5):1257-1265 - PMID: 28435463 - PMCID: PMC5399591 - DOI: 10.7150/thno.18238

  • Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017;169:510-522 - PMID: 28431249 - PMCID: PMC5474950 - DOI: 10.1016/j.cell.2017.03.050

  • Seo KJ, Qiang Y, Bilgin I, Kar S, Vinegoni C, Weissleder R, Fang H Transparent Electrophysiology Microelectrodes and Interconnects from Metal Nanomesh. ACS Nano. 2017;11(4):4365-4372 - PMID: 28391679 - DOI: 10.1021/acsnano.7b01995

  • Lee S, Courties G, Nahrendorf M, Weissleder R, Vinegoni C Motion characterization scheme to minimize motion artifacts in intravital microscopy. J Biomed Opt. 2017;22(3):36005 - PMID: 28253383 - PMCID: PMC5333764 - DOI: 10.1117/1.JBO.22.3.036005

  • Giedt RJ, Fumene Feruglio P, Pathania D, Yang KS, Kilcoyne A, Vinegoni C, Mitchison TJ, Weissleder R Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response. Sci Rep. 2016;6:32985 - PMID: 27609668 - PMCID: PMC5017129 - DOI: 10.1038/srep32985

  • Clardy SM, Kohler RH, Vinegoni C, Iwamoto Y, Keliher EJ, Weissleder R Two-photon imaging of pancreatic beta cells in real time in vivo. Technology. 2016;4(2):130-134

  • Vinegoni C, Dubach JM, Feruglio PF, Weissleder R Two-Photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement. IEEE J Sel Top Quant. 2016;22 (3):6801607 - PMID: 27440991 - PMCID: PMC4946648 - DOI: 10.1109/JSTQE.2015.2501384

  • Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction. Sci Transl Med. 2016;8:342 - PMID: 27280687 - PMCID: PMC5125383 - DOI: 10.1126/scitranslmed.aaf1435

  • Vinegoni C, Leon Swisher C, Fumene Feruglio P, Giedt RJ, Rousso DL, Stapleton S, Weissleder R Real-time high dynamic range laser scanning microscopy. Nat Commun. 2016;7:11077 - PMID: 27032979 - PMCID: PMC4821995 - DOI: 10.1038/ncomms11077

  • Roy J*, Kim B*, Hill E, Visconti P, Krapf D, Vinegoni C, Weissleder R, Brown D, Breton S Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging. Nat Commun. 2016;7:10666 - PMID: 26868824 - PMCID: PMC4754344 - DOI: 10.1038/ncomms10666

  • Vinegoni C, Aguirre AD, Lee S, Weissleder R Imaging the beating heart in the mouse using intravital microscopy techniques. Nat Protoc. 2015;10(11):1802-1819 - PMID: 26492138 - PMCID: PMC5380003 - DOI: 10.1038/nprot.2015.119

  • Clardy SM, James F. Mohan JF, Vinegoni C, Keliher EJ, Iwamoto Y, Benoist C, Mathis D, Weissleder R Rapid, high efficiency isolation of pancreatic ß-cells. Sci Rep. 2015;5:13681 - PMID: 26330153 - PMCID: PMC4557033 - DOI: 10.1038/srep13681

  • Vinegoni C, Lee S, Aguirre AD, Weissleder R New techniques for motion-artifact-free in vivo cardiac microscopy. Front Physiol. 2015;6:147 - PMID: 26029116 - PMCID: PMC4428079 - DOI: 10.3389/fphys.2015.00147

  • Vinegoni C, Dubach JM, Thurber GM, Miller MA, Mazitschek R, Weissleder R Advances in measuring single-cell pharmacokinetics and pharmacology in vivo. Drug Discov Today. 2015;20(9):1087-92 - PMID: 26024776 - PMCID: PMC4567932 - DOI: 10.1016/j.drudis.2015.05.011

  • Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells. Cell Stem Cell. 2015;16 (5):477-487 - PMID: 25957903 - PMCID: PMC4426344 - DOI: 10.1016/j.stem.2015.04.008

  • Dubach JM, Vinegoni C, Weissleder R Steady state anisotropy two-photon microscopy resolves multiple, spectrally similar fluorophores, enabling in vivo multilabel imaging. Opt Lett. 2014;39(15):4482-4485 - PMID: 25078208 - PMCID: PMC4341989 - DOI: 10.1364/OL.39.004482

  • Aguirre AD, Vinegoni C, Sebas M, Weissleder R Intravital imaging of cardiac function at the single-cell level. Proc Natl Acad Sci U S A. 2014;111(31):11257-62 - PMID: 25053815 - PMCID: PMC4128110 - DOI: 10.1073/pnas.1401316111

  • Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M Chronic variable stress activates hematopoietic stem cells. Nature Med. 2014;20(7):754-758 - PMID: 24952646 - PMCID: PMC4087061 - DOI: 10.1038/nm.3589

  • Dubach JM, Vinegoni C, Mazitschek R, Fumene Feruglio P, Cameron LA, Weissleder R In vivo imaging of specific drug-target binding at subcellular resolution. Nat Commun. 2014;5:3946 - PMID: 24867710 - PMCID: PMC4362617 - DOI: 10.1038/ncomms4946

  • Lee S, Vinegoni C, Sebas M, Weissleder R Automated motion artifact removal for intravital microscopy, without a priori information. Sci Rep. 2014;4:4507 - PMID: 24676021 - PMCID: PMC3968488 - DOI: 10.1038/srep04507

  • Vinegoni C, Lee S, Feruglio PF, Weissleder R Advanced Motion Compensation Methods for Intravital Optical Microscopy. IEEE J Sel Top Quant. 2014;20(2):ePub - PMID: 24273405 - PMCID: PMC3832946 - DOI: 10.1109/JSTQE.2013.2279314

  • Vinegoni C, Lee S, Feruglio PF, Marzola P, Nahrendorf M, Weissleder R Sequential average segmented microscopy for high signal-to-noise ratio motion-artifact-free in vivo heart imaging. Biomed Opt Express. 2013;4(10):2095-106 - PMID: 24156067 - PMCID: PMC3799669 - DOI: 10.1364/BOE.4.002095

  • Vinegoni C, Lee S, Gorbatov R, Weissleder R Motion compensation using a suctioning stabilizer for intravital microscopy. Intravital. 2012;1:115-121 - PMID: 24086796 - PMCID: PMC3786172 - DOI: 10.4161/intv.23017

  • Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Hatfield K, Enger M, Shafiee S, McCormack E, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B Implantable microenvironments to attract hematopoietic stem/cancer cells. Proc Natl Acad Sci U S A. 2012;109(48):19638-43 - PMID: 23150542 - PMCID: PMC3511730 - DOI: 10.1073/pnas.1208384109

  • Lee S, Vinegoni C, Feruglio PF, Weissleder R Improved intravital microscopy via synchronization of respiration and holder stabilization. J Biomed Opt. 2012;17(9):96018-1 - PMID: 23085919 - PMCID: PMC3449295 - DOI: 10.1117/1.JBO.17.9.096018

  • Lee S, Vinegoni C, Feruglio PF, Fexon L, Gorbatov R, Pivovarov M, Sbarbati A, Nahrendorf M, Weissleder R Real-time in vivo imaging of the beating mouse heart at microscopic resolution. Nat Commun. 2012;3:1054 - PMID: 22968700 - PMCID: PMC3622400 - DOI: 10.1038/ncomms2060

  • Lu X, Agasti SS, Vinegoni C, Waterman P, Depinho R, Weissleder R Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators. Bioconjug Chem. 2012;23(9):1945-51 - PMID: 22917215 - PMCID: PMC3775343 - DOI: 10.1021/bc300319c

  • Feruglio PF, Vinegoni C, Fexon L, Thurber G, Sbarbati A, Weissleder R Noise suppressed, multifocus image fusion for enhanced intraoperative navigation. J Biophotonics. 2012;6(4):363-70 - PMID: 22887724 - PMCID: PMC3779878 - DOI: 10.1002/jbio.201200086

  • Dutta P*, Courties G*, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AN, Niessen HWM, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M Myocardial infarction accelerates atherosclerosis. Nature. 2012;487(7407):325-9 - PMID: 22763456 - PMCID: PMC3401326 - DOI: 10.1038/nature11260

  • Yang KS, Budin G, Reiner T, Vinegoni C, Weissleder R Bioorthogonal Imaging of Aurora Kinase A in Live Cells. Angew Chem Int Ed Engl. 2012;51(27):6598-603 - PMID: 22644700 - PMCID: PMC3523717 - DOI: 10.1002/anie.201200994

  • Vinegoni C, Feruglio PF, Razansky D, Gorbatov R, Ntziachristos V, Sbarbati A, Nahrendorf M, Weissleder R Mapping molecular agents distributions in whole mice hearts using born-normalized optical projection tomography. PLoS ONE. 2012;7(4):e34427 - PMID: 22509302 - PMCID: PMC3324534 - DOI: 10.1371/journal.pone.0034427

  • Earley S, Vinegoni C, Dunham J, Gorbatov R, Fumene Feruglio P, Weissleder R In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single cell resolution. Cancer Res. 2012;72(12):2949-56 - PMID: 22505651 - PMCID: PMC3603290 - DOI: 10.1158/0008-5472.CAN-11-4096

  • Razansky D, Deliolanis N, Vinegoni C, Ntziachristos V Deep Tissue Optical and Optoacoustic Molecular Imaging Technologies for Small Animal Research and Drug Discovery. Curr Pharm Biotechnol. 2012;13(4):504-22 - PMID: 22216767 - DOI: 10.2174/138920112799436258

  • Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, Dutta P, Iwamoto Y, Ueno T, Begieneman MPV, Niessen HWM, Piek JJ, Vinegoni C, Pittet MJ, Swirski FK, Tawakol A, Di Carli M, Weissleder R, Nahrendorf M PET/MRI of Inflammation in Myocardial Infarction. J Am Coll Cardiol. 2012;59:153-163 - PMID: 22222080 - PMCID: PMC3257823 - DOI: 10.1016/j.jacc.2011.08.066

  • Haase A, Rigosi E, Frasnelli E, Trona F, Tessarolo F, Vinegoni C, Anfora G, Vallortigara G, Antolini R A multimodal approach for tracing lateralisation along the olfactory pathway in the honeybee through electrophysiological recordings, morpho-functional imaging, and behavioural studies. Eur Biophys J. 2011;40(11):1247-1258 - PMID: 21956452 - PMCID: PMC3366498 - DOI: 10.1007/s00249-011-0748-6

  • Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C, Mathis D, Weissleder R Accurate measurement of pancreatic islet {beta}-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A. 2011;108(31):12815-20 - PMID: 21768367 - PMCID: PMC3150928 - DOI: 10.1073/pnas.1109859108

  • Vinegoni C, Botnaru I, Aikawa E, Calfon MA, Iwamoto Y, Folco EJ, Ntziachristos V, Weissleder R, Libby P, Jaffer FA Indocyanine Green Enables Near-Infrared Fluorescence Imaging of Lipid-Rich, Inflamed Atherosclerotic Plaques. Sci Transl Med. 2011;3 (84) ra45):84ra45 - PMID: 21613624 - PMCID: PMC3112179 - DOI: 10.1126/scitranslmed.3001577

  • Rigosi E, Frasnelli E, Vinegoni C, Antolini R, Anfora G, Vallortigara G, Haase A Searching for anatomical correlates of olfactory lateralization in the honeybee antennal lobes: A morphological and behavioural study. Behav Brain Res.. 2011;221(1):290-4 - PMID: 21402106 - PMCID: PMC3089663 - DOI: 10.1016/j.bbr.2011.03.015

  • Figueiredo JL, Nahrendorf M, Vinegoni C, Weissleder R Intraoperative Near-infrared Fluorescent Cholangiography (NIRFC) in Mouse Models of Bile Duct Injury: Reply. World J Surg. 2011;35(3):694-5 - PMID: 20645091 - DOI: 10.1007/s00268-010-0728-5

  • Haase A, Rigosi E, Trona F, Anfora G, Vallortigara G, Antolini R, Vinegoni C In-vivo two-photon imaging of the honey bee antennal lobe. Biomed Opt Express. 2010;2(1):131-8 - PMID: 21326643 - PMCID: PMC3028488 - DOI: 10.1364/BOE.1.000131

  • Gros J, Hu JK, Vinegoni C, Feruglio PF, Weissleder R, Tabin CJ WNT5A/JNK and FGF/MAPK Pathways Regulate the Cellular Events Shaping the Vertebrate Limb Bud. Curr Top Dev Biol. 2010;20(22):1993-2002 - PMID: 21055947 - PMCID: PMC2998074 - DOI: 10.1016/j.cub.2010.09.063

  • Fumene Feruglio P, Vinegoni C, Gros J, Sbarbati A, Weissleder R Block matching 3D random noise filtering for absorption optical projection tomography. Phys Med Biol. 2010;55(18):5401-5415 - PMID: 20736500 - PMCID: PMC2934766 - DOI: 10.1088/0031-9155/55/18/009

  • Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF, Fexon L, Pivovarov M, Swirski FK, Pittet MJ, Vinegoni C, Weissleder R Hybrid PET-optical imaging using targeted probes. Proc Natl Acad Sci U S A. 2010;107(17):7910-5 - PMID: 20385821 - PMCID: PMC2867879 - DOI: 10.1073/pnas.0915163107

  • Vinegoni C, Fumene Feruglio P, Cortez-Retamozo V, Razansky D, Medoff BD, Ntziachristos V, Sbarbati A, Pittet M, Weissleder R Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography. Opt Lett. 2010;35(7):1088-90 - PMID: 20364226 - PMCID: PMC2900933 - DOI: 10.1364/OL.35.001088

  • Calfon MA, Vinegoni C, Ntziachristos V, Jaffer FA Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques. J Biomed Opt. 2010;15(1):011107 - PMID: 20210433 - PMCID: PMC3188610 - DOI: 10.1117/1.3280282

  • Vinegoni C, Fexon L, Fumene Feruglio P, Pivovarov M, Figueiredo JL, Nahrendorf M, Pozzo A, Sbarbati A, Weissleder R High throughput transmission optical projection tomography using low cost graphics processing unit. Opt Express. 2009;17(25):22320-22332 - PMID: 20052155 - PMCID: PMC2805020 - DOI: 10.1364/OE.17.022320

  • Tsai CC, Vinegoni C, Weissleder R Diffractionless beam in free space with adiabatic changing refractive index in a single mode tapered slab waveguide. Opt Express. 2009;17(24):21723-31 - PMID: 19997414 - PMCID: PMC2805120 - DOI: 10.1364/OE.17.021723

  • Vinegoni C, Razansky D, Hilderbrand SA, Shao F, Ntziachristos V, Weissleder R Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles. Opt Lett. 2009;34(17):2566-8 - PMID: 19724491 - PMCID: PMC2749971 - DOI: 10.1364/OL.34.002566

  • Vinegoni C, Razansky D, Pitsouli C, Perrimon N, Ntziachristos V, Weissleder R Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila. J Vis Exp. 2009;(30):pii:1510 - PMID: 19696720 - PMCID: PMC2736679 - DOI: 10.3791/1510

  • Razansky D, Distel M, Vinegoni C, Ma R, Perrimon N, Koster RW, Ntziachristos V Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo. Nat Photonics. 2009;3:412 - 417

  • Razansky D, Vinegoni C, Ntziachristos V Unprecedented in vivo views at the mesoscopic scale. Biooptics World. 2009;2 (4):22-25

  • Vinegoni C, Razansky D, Figueiredo JL, Fexon L, Pivovarov M, Nahrendorf M, Ntziachristos V, Weissleder R Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging. J Vis Exp. 2009;28:1389 - PMID: 19578329 - PMCID: PMC2794886 - DOI: 10.3791/1389

  • Razansky D, Vinegoni C, Ntziachristos V Imaging of mesoscopic-scale organisms using selective-plane optoacoustic tomography. Phys Med Biol. 2009;54:2769-2777 - PMID: 19369709 - DOI: 10.1088/0031-9155/54/9/012

  • Vinegoni C, Razansky D, Figueiredo JL, Nahrendorf M, Ntziachristos V, Weissleder R Normalized Born ratio for fluorescence optical projection tomography. Opt Lett. 2009;34(3):319-21 - PMID: 19183644 - PMCID: PMC2771918 - DOI: 10.1364/ol.34.000319

  • Cortez-Retamozo V, Swirski FK, Waterman P, Yuan H, Figueiredo JL, Newton AP, Upadhyay R, Vinegoni C, Kohler R, Blois J, Smith A, Nahrendorf M, Josephson L, Weissleder R, Pittet MJ Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. J Clin Invest. 2008;118(12):4058-66 - PMID: 19033674 - PMCID: PMC2579705 - DOI: 10.1172/JCI36335

  • Razansky D, Vinegoni C, Ntziachristos V Polarization-sensitive optoacoustic tomography of optically diffuse tissues. Opt Lett. 2008;33(20):2308-10 - PMID: 18923605 - DOI: 10.1364/ol.33.002308

  • Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK, Finn AV, Ntziachristos V, Libby P, Weissleder R Real-Time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis. Circulation. 2008;118(18):1802-9 - PMID: 18852366 - PMCID: PMC2729441 - DOI: 10.1161/CIRCULATIONAHA.108.785881

  • Tan W, Vinegoni C, Norman J, Desai T, Boppart S Imaging cellular responses to mechanical stimuli within three-dimensional tissue constructs. Microsc Res Techniq. 2007;70(4):361-71 - PMID: 17262787 - DOI: 10.1002/jemt.20420

  • Razansky D, Vinegoni C, Ntziachristos V Multispectral photoacoustic imaging of fluorochromes in small animals. Opt Lett. 2007;32(19):2891-3 - PMID: 17909608 - DOI: 10.1364/ol.32.002891

  • Vinegoni C, Ralston T, Tan W, Luo W, Marks DL, Boppart SA Integrated structural and functional imaging combining spectral-domain optical coherence and multiphoton microscopy. Appl Phys Lett. 2006;88:051105

  • Xu C, Vinegoni C, Ralston T, Luo W, Tan W, Boppart S Spectroscopic spectral-domain optical coherence microscopy. Opt Lett. 2006;31:1079-81 - PMID: 16625909 - DOI: 10.1364/ol.31.001079

  • Jones G, Marks D, Vinegoni C, Boppart S High-spectral-resolution coherent anti-Stokes Raman scattering with interferometrically detected broadband chirped pulses. Opt Lett. 2006;31(10):1543-5 - PMID: 16642166 - DOI: 10.1364/ol.31.001543

  • Marks DL, Vinegoni C, Bredfeldt J, Boppart SA Nonlinear Interferometric Vibrational Imaging. efficient detection of Coherent Anti-Stokes Raman Scattering. OPN Special Issue, Optics in 2005. 2005;16:23

  • Vinegoni C, Bredfeldt J, Marks D, Boppart S Nonlinear optical contrast enhancement for optical coherence tomography. Opt Express. 2004;12:331-41 - PMID: 19471542 - DOI: 10.1364/opex.12.000331

  • Vinegoni C, Karlsson M, Petersson M, Sunnerud H Statistics of polarization-dependent loss in a recirculating loop. J Lightwave Technol. 2004;22:968-76

  • Marks DL, Vinegoni C, Bredfeldt JS, Boppart SA Interferometric differentiation between resonant Coherent Anti-Stokes Raman Scattering and nonresonant four-wave-mixing processes . Appl Phys Lett. 2004;85:5787-89

  • Vinegoni C, Chen H, Leblanc M, Schinn G, Wegmulller M, Gisin N Distributed measurements of chromatic dispersion and nonlinear coefficient in low PMD dispersion shifted fibers. IEEE Photonic Tech L. 2003;15:739-40

  • Petersson M, Vinegoni C, Sunnerud H, Karlsson M Statistics of PMD in recirculating loops. . IEEE Photonic Tech L. 2003;15:1543-5

  • Wegmuller M, Demma S, Vinegoni C, Gisin N Emulator of first- and second-order polarization mode dispersion. IEEE Photonic Tech L. 2002;14:630-2

  • Vinegoni C, Wegmuller M, Gisin N Measurements of the nonlinear coefficient of standard SMF,DSF, and DSC fibers using a self-aligned interferometer and a Faraday mirror. IEEE Photonic Tech L. 2001;13:1337-9

  • Vinegoni C, Cazzanelli M, Trivelli A, Lunney GJ, Mariotto G, Levy J Morphological and optical characterization of GaN prepared by pulsed laser ablation. Surf Coat Tech. 2000;124:272-7

  • Pirri P, Vinegoni C, Pavesi L Optical and photoluminescence properties of a-Si(1-x)Nx:H films deposited by PECVD . Phys Rev B. 2000;61:4693-8

  • Cazzanelli E, Mariotto G, Vinegoni C, Kuzmin A, Purans J Color centers and polymorphism in pure and WO3 and mixed ReO3-WO3 powders. Ionics 2000;5;335-44 . Ionics. 2000;5:335-44

  • Vinegoni C, Wegmuller M, Huttner B, Gisin N Measurement of nonlinear polarization rotation in high birefringence optical fibers at telecom wavelength. 2000;2;314-184 . J Opt A-Pure Appl Opt . 2000;2:314-184

  • Vinegoni C, Wegmuller M, Huttner B, Gisin N All optical switching in a highly birefringent and a standard telecom fiber using a Faraday mirror stabilization scheme. Opt Commun. 2000;182:314-18

  • Vinegoni C, Wegmuller M, Gisin N Determination of the nonlinear coefficient n2/Aeff using a self-aligned interferometer and a Faraday mirror. . 2000;36;886. Electronic Lett. 2000;36:886-87

  • Wegmuller M, Oberson P, Guinnard O, Huttner B, Guinnard L, Vinegoni C, Gisin N Distributed gain measurements in Er-doped fibers with high resolution and accuracy using an Optical Frequency Domain Reflectometer. J Lightwave Technol. 2000;18:2127-32

  • Wegmuller M, Legre M, Oberson P, Guinnard O, Guinnard L, Vinegoni C, Gisin N Analysis of the polarization evolution in a ribbon cable using high resolution OFDR. IEEE Photonic Tech L. 2000;13:145-7

  • Cazzanelli E, Vinegoni C, Mariotto G, Kuzmin A, Purans J Comparative Raman study of the monoclinic-to-tetragonal phase transition in tungsten trioxide WO3 at high temperature and upon hydrogen insertion. J Solid State Chem. 1999;143:24-32

  • Cazzanelli E, Vinegoni C, Mariotto G, Kuzmin A, Purans J Raman and XRD spectroscopic investigations of polymorphism in tungsten trioxide powders. Solid State Ionics. 1999;123:67-74

  • Giorgis F, Pirri CF, Vinegoni C, Pavesi L Luminescence processes in amorphous silicon-nitride nanometric multilayers . Phys Rev B. 1999;60:11572-76

  • Cazzanelli M, Vinegoni C, Pavesi L Temperature dependence of the photo luminescence of all porous silicon microcavities. J. Appl. Phys. 1999;85;1760-4. J Appl Physiol. 1999;85:1760-4

  • Cazzanelli M, Vinegoni C, Lunney JG, O'Donnel KP, Middleton PG, Trager-Cowan C, Pavesi L Luminescence properties of GaN thin films prepared by pulsed laser deposition. Mat Sci Eng B-Solid. 1999;59:137-140

  • Pellegrini V, Colombelli R, Vinegoni C, Rubini S, Lantier R, Franciosi A, Beltram F, Pavesi L Second harmonic generation in ZnSe microcavity. Appl. Phys. Lett. 1999;74:1945-47. Appl Phys Lett. 1999;74:1945-47

  • Kuzmin A, Purans J, Cazzanelli E, Vinegoni C, Mariotto G XRD, EXAFS and Raman spectroscopy studies of pure ground WO3 and mixed W1-xRexO3-y polycrystals. J Appl Phys. 1998;84:5515-24

  • Giorgis F, Pirri CF, Vinegoni C, Pavesi L Radiative emission properties of a-SiN:H based alloys, nanometric multilayers and light emitting devices. J Lumin. 1998;80:423-427

  • Cazzanelli M, Cole D, Donegan JF, Lunney JG, Middleton PG, O'Donnell KP, Vinegoni C, Pavesi L Photoluminescence of localized excitons in pulsed laser deposited GaN. Appl Phys Lett. 1998;73:3390-2