Breton, Sylvie, PhD

Professor

Richard Moerschner Endowed MGH Research Institute Chair in Men's Health

Phone: 617-643-3182, 617-726-5785
Email: Breton.Sylvie@mgh.harvard.edu
Lab: Breton, Sylvie

Sylvie Breton is a PhD in Biophysics who specializes in the cell biology of membrane transport. She studies luminal acidification and intercellular communication networks in the kidney and epididymis. She became Professor of Medicine at Harvard Medical School in 2012, and she has been at MGH since 1994.

Publications

  • Hoyer FF*, Naxerova K*, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge. Immunity. 2019;51(5):899-914.e7 - PMID: 31732166 - PMCID: PMC6892583 - DOI: 10.1016/j.immuni.2019.10.010

  • Battistone MA, Spallanzani RG, Mendelsohn AC, Capen D, Nair AV, Brown D, Breton S Novel role of proton-secreting epithelial cells in sperm maturation and mucosal immunity. J Cell Sci. 2019;:ePub - PMID: 31636115 - PMCID: PMC7003979 - DOI: 10.1242/jcs.233239

  • Breton S, Nair AV, Battistone MA Epithelial dynamics in the epididymis: role in the maturation, protection, and storage of spermatozoa. Andrology. 2019;7(5):631-643 - PMID: 31044554 - PMCID: PMC6688936 - DOI: 10.1111/andr.12632

  • Sullivan R, Légaré C, Lamontagne-Proulx J, Breton S, Soulet D Revisiting structure/functions of the human epididymis. Andrology. 2019;7(5):748-757 - PMID: 31033221 - DOI: 10.1111/andr.12633

  • Battistone MA, Merkulova M, Park YJ, Peralta MA, Gombar F, Brown D, Breton S Unraveling purinergic regulation in the epididymis: Activation of V-ATPase-dependent acidification by luminal ATP and adenosine. J Physiol. 2019;597(7):1957-1973 - PMID: 30746715 - PMCID: PMC6441927 - DOI: 10.1113/JP277565

  • Carvajal G, Brukman NG, Weigel Muñoz M, Battistone MA, Guazzone VA, Ikawa M, Haruhiko M, Lustig L, Breton S, Cuasnicu PS Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4. Sci Rep. 2018;8(1):17531 - PMID: 30510210 - PMCID: PMC6277452 - DOI: 10.1038/s41598-018-35719-3

  • Breton S, Brown D Novel Proinflammatory Function of Renal Intercalated Cells. Ann Nutr Metab. 2018;72 Suppl 2:11-16 - PMID: 29925073 - DOI: 10.1159/000488303

  • Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA Reply to Edemir: Physiological regulation and single-cell RNA sequencing. Proc Natl Acad Sci U S A. 2018;115(3):E351-E352 - PMID: 29311339 - PMCID: PMC5777009 - DOI: 10.1073/pnas.1720333115

  • Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq. Proc Natl Acad Sci U S A. 2017;114(46):E9989-E9998 - PMID: 29089413 - PMCID: PMC5699061 - DOI: 10.1073/pnas.1710964114

  • Park YJ, Battistone MA, Kim B, Breton S Relative contribution of clear cells and principal cells to luminal pH in the mouse epididymis. Biol Reprod. 2017;96(2):366-375 - PMID: 28203710 - PMCID: PMC6213081 - DOI: 10.1095/biolreprod.116.144857

  • Cotter K, Liberman R, Sun-Wada G, Wada Y, Sgroi D, Naber S, Brown D, Breton S, Forgac M The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer. Oncotarget. 2016;7(29):46142-46157 - PMID: 27323815 - PMCID: PMC5216787 - DOI: 10.18632/oncotarget.10063

  • Roy J*, Kim B*, Hill E, Visconti P, Krapf D, Vinegoni C, Weissleder R, Brown D, Breton S Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging. Nat Commun. 2016;7:10666 - PMID: 26868824 - PMCID: PMC4754344 - DOI: 10.1038/ncomms10666

  • Breton S, Ruan YC, Park YJ, Kim B Regulation of epithelial function, differentiation, and remodeling in the epididymis. Asian J Androl. 2015;18(1):3-9 - PMID: 26585699 - PMCID: PMC4736353 - DOI: 10.4103/1008-682X.165946

  • Merkulova M, Păunescu TG, Azroyan A, Marshansky V, Breton S, Brown D Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation. Sci Rep. 2015;5:14827 - PMID: 26442671 - PMCID: PMC4595830 - DOI: 10.1038/srep14827

  • Kim B, Breton S Localization of the gap junction protein, connexin 43, and E-cadherin/Cadherin-1 in the proximal mouse epididymis. Mol Reprod Dev. 2015;82(10):723 - PMID: 26331361

  • Azroyan A, Cortez-Retamozo V, Bouley R, Liberman R, Ruan YC, Kiselev E, Jacobson KA, Pittet MJ, Brown D, Breton S Renal Intercalated Cells Sense and Mediate Inflammation via the P2Y14 Receptor. PLoS ONE. 2015;10(3):e0121419 - PMID: 25799465 - PMCID: PMC4370445 - DOI: 10.1371/journal.pone.0121419

  • Ruan YC, Wang Y, Da Silva N, Kim B, Diao RY, Hill E, Brown D, Chan HC, Breton S CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation via the ZONAB pathway. J Cell Sci. 2014;127(Pt 20):4396-408 - PMID: 25107366 - PMCID: PMC4197086 - DOI: 10.1242/jcs.148098

  • Păunescu TG, Shum WW, Huynh C, Lechner L, Goetze B, Brown D, Breton S High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa. Mol Hum Reprod. 2014;20(10):929-37 - PMID: 25015675 - PMCID: PMC4172170 - DOI: 10.1093/molehr/gau052

  • Jun HJ, Roy J, Smith TB, Wood LB, Lane K, Woolfenden S, Punko D, Bronson RT, Haigis KM, Breton S, Charest A ROS1 Signaling Regulates Epithelial Differentiation in the Epididymis. Endocrinology. 2014;:en20141341 - PMID: 24971615 - PMCID: PMC4138574 - DOI: 10.1210/en.2014-1341

  • Shum WW, Smith TB, Cortez-Retamozo V, Grigoryeva LS, Roy JW, Hill E, Pittet MJ, Breton S, Da Silva N Epithelial Basal Cells Are Distinct from Dendritic Cells and Macrophages in the Mouse Epididymis. Biol Reprod. 2014;90(5):90 - PMID: 24648397 - PMCID: PMC4076373 - DOI: 10.1095/biolreprod.113.116681

  • Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature. 2013;503(7475):218-23 - PMID: 24196716 - PMCID: PMC4035230 - DOI: 10.1038/nature12777

  • Paunescu TG, Lu HA, Russo LM, Pastor-Soler NM, McKee M, McLaughlin MM, Bartlett BE, Breton S, Brown D Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells. Am J Physiol Renal Physiol. 2013;305(12):F1783-F1795 - PMID: 24133120 - PMCID: PMC3882446 - DOI: 10.1152/ajprenal.00622.2012

  • Breton S, Brown D Regulation of Luminal Acidification by the V-ATPase. Physiology (Bethesda). 2013;28(5):318-29 - PMID: 23997191 - PMCID: PMC3768094 - DOI: 10.1152/physiol.00007.2013

  • Shum W, Hill E, Brown D, Breton S Plasticity of basal cells during postnatal development in the rat epididymis. Reproduction. 2013;146(5):455-469 - PMID: 23960170 - PMCID: PMC4106237 - DOI: 10.1530/REP-12-0510

  • Roy JW, Hill E, Ruan YC, Vedovelli L, Paunescu T, Brown D, Breton S Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymis. Am J Physiol Cell Physiol. 2013;305(4):C436-46 - PMID: 23761626 - PMCID: PMC3891217 - DOI: 10.1152/ajpcell.00410.2012

  • Kim JK, Vinarsky V, Wain JC, Zhao R, Jung K, Choi J, Lam A, Pardo-Saganta A, Breton S, Rajagopal J, Yun SH In vivo imaging of tracheal epithelial cells in mice during airway regeneration. Am J Respir Cell Mol Biol. 2012;47(6):864-8 - PMID: 22984086 - PMCID: PMC3547097 - DOI: 10.1165/rcmb.2012-0164OC

  • Krapf D, Chun Ruan Y, Wertheimer EV, Battistone MA, Pawlak JB, Sanjay A, Pilder SH, Cuasnicu P, Breton S, Visconti PE cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit. Dev Biol. 2012;369(1):43-53 - PMID: 22750823 - PMCID: PMC3424100 - DOI: 10.1016/j.ydbio.2012.06.017

  • Ruan YC, Shum WW, Belleannée C, Da Silva N, Breton S ATP secretion in the male reproductive tract: essential role of CFTR. J Physiol. 2012;590(Pt 17):4209-22 - PMID: 22711960 - PMCID: PMC3473280 - DOI: 10.1113/jphysiol.2012.230581

  • Staropoli JF, Haliw L, Biswas S, Garrett L, Hölter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, Sun M, Favor J, Racz I, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Lopez E, Harati H, Hill E, Krause DS, Guide J, Dragileva E, Gale E, Wheeler VC, Boustany RM, Brown DE, Breton S, Ruether K, Gailus-Durner V, Fuchs H, de Angelis MH, Cotman SL Large-Scale Phenotyping of an Accurate Genetic Mouse Model of JNCL Identifies Novel Early Pathology Outside the Central Nervous System. PLoS ONE. 2012;7(6):e38310 - PMID: 22701626 - PMCID: PMC3368842 - DOI: 10.1371/journal.pone.0038310

  • Brown D, Bouley R, Paunescu TG, Breton S, Lu HA New insights into the dynamic regulation of water and acid/base balance by renal epithelial cells. Am J Physiol Cell Physiol. 2012;302(10):C1421-33 - PMID: 22460710 - PMCID: PMC3362000 - DOI: 10.1152/ajpcell.00085.2012

  • Wagner CA, Mohebbi N, Uhlig U, Giebisch GH, Breton S, Brown D, Geibel JP Angiotensin II Stimulates H-ATPase Activity in Intercalated Cells from Isolated Mouse Connecting Tubules and Cortical Collecting Ducts. Cell Physiol Biochem. 2011;28(3):513-20 - PMID: 22116365 - PMCID: PMC3709473 - DOI: 10.1159/000335112

  • Shum WW, Ruan YC, Da Silva N, Breton S Establishment of Cell-Cell Crosstalk in the Epididymis: Control of Luminal Acidification. J Androl. 2011;32(6):576-86 - PMID: 21441423 - PMCID: PMC3753098 - DOI: 10.2164/jandrol.111.012971

  • Shum WW, Da Silva N, Belleannee C, McKee M, Brown D, Breton S Regulation of V-ATPase recycling via a RhoA and ROCKII dependent pathway in epididymal clear cells. Am J Physiol Cell Physiol. 2011;301(1):C31-43 - PMID: 21411727 - PMCID: PMC3129830 - DOI: 10.1152/ajpcell.00198.2010

  • Da Silva N, Cortez-Retamozo V, Reinecker HC, Wildgruber M, Hill E, Brown D, Swirski F, Pittet M, Breton S A dense network of dendritic cells populates the murine epididymis. Reproduction. 2011;141(5):653-63 - PMID: 21310816 - PMCID: PMC3657760 - DOI: 10.1530/REP-10-0493

  • Da Silva N, Pisitkun T, Belleannee C, Miller LR, Nelson RD, Knepper MA, Brown D, Breton S Proteomic analysis of V-ATPase-rich cells harvested from the kidney and epididymis by fluorescence activated cell sorting. Am J Physiol Cell Physiol. 2010;298(6):C1326-42 - PMID: 20181927 - PMCID: PMC2889637 - DOI: 10.1152/ajpcell.00552.2009

  • Belleannee C, Da Silva N, Shum WW, Brown D, Breton S Role of purinergic signaling pathways in V-ATPase recruitment to the apical membrane of acidifying epididymal clear cells. Am J Physiol Cell Physiol. 2010;298(4):C817-30 - PMID: 20071692 - PMCID: PMC2853219 - DOI: 10.1152/ajpcell.00460.2009

  • Paunescu TG, Ljubojevic M, Russo LM, Winter C, McLaughlin MM, Wagner CA, Breton S, Brown D Cyclic AMP stimulates apical V-ATPase accumulation, microvillar elongation and proton extrusion in kidney collecting duct A-intercalated cells. Am J Physiol Renal Physiol. 2010;298(3):F643-54 - PMID: 20053793 - PMCID: PMC2838605 - DOI: 10.1152/ajprenal.00584.2009

  • Shum WW, Da Silva N, Brown D, Breton S Regulation of luminal acidification in the male reproductive tract via cell-cell crosstalk. J Exp Biol. 2009;212(Pt 11):1753-61 - PMID: 19448084 - PMCID: PMC2683015 - DOI: 10.1242/jeb.027284

  • Brown D, Paunescu TG, Breton S, Marshansky V Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking. J Exp Biol. 2009;212(Pt 11):1762-72 - PMID: 19448085 - PMCID: PMC2683016 - DOI: 10.1242/jeb.028803

  • Vidarsson H, Westergren R, Heglind M, Blomqvist SR, Breton S, Enerback S The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis. PLoS ONE. 2009;4(2):e4471 - PMID: 19214237 - PMCID: PMC2637605 - DOI: 10.1371/journal.pone.0004471

  • Brown D, Breton S, Ausiello DA, Marshansky V Sensing, Signaling and Sorting Events in Kidney Epithelial Cell Physiology. Traffic. 2009;10(3):275-84 - PMID: 19170982 - PMCID: PMC2896909 - DOI: 10.1111/j.1600-0854.2008.00867.x

  • Belleannee C, Da Silva N, Shum WW, Marsolais M, Laprade R, Brown D, Breton S Segmental Expression of the Bradykinin Type 2 Receptor in Rat Efferent Ducts and Epididymis and Its Role in the Regulation of Aquaporin 9. Biol Reprod. 2009;80(1):134-43 - PMID: 18829705 - PMCID: PMC2804812 - DOI: 10.1095/biolreprod.108.070797

  • Shum WW, Da Silva N, McKee M, Smith PJ, Brown D, Breton S Transepithelial Projections from Basal Cells are Luminal Sensors in Pseudostratified Epithelia. Cell. 2008;135:1108-17 - PMID: 19070580 - PMCID: PMC2646085 - DOI: 10.1016/j.cell.2008.10.020

  • Pastor-Soler NM, Hallows KR, Smolak C, Gong F, Brown D, Breton S Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol. 2008;294:C488-94 - PMID: 18160485 - PMCID: PMC4303256 - DOI: 10.1152/ajpcell.00537.2007

  • Da Silva N, Shum WW, Breton S Regulation of vacuolar proton pumping ATPase-dependent luminal acidification in the epididymis. Asian J Androl. 2007;9(4):476-82 - PMID: 17589784 - DOI: 10.1111/j.1745-7262.2007.00299.x

  • Paunescu TG, Russo LM, Da Silva N, Kovacikova J, Mohebbi N, Van Hoek AN, McKee M, Wagner CA, Breton S, Brown D Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice. Am J Physiol Renal Physiol. 2007;293(6):F1915-26 - PMID: 17898041 - DOI: 10.1152/ajprenal.00160.2007

  • Da Silva N, Shum WW, El-Annan J, Paunescu TG, McKee M, Smith PJ, Brown D, Breton S Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit. Am J Physiol Cell Physiol. 2007;293(1):C199-210 - PMID: 17392376 - DOI: 10.1152/ajpcell.00596.2006

  • Da Silva N, Pietrement C, Brown D, Breton S Segmental and cellular expression of aquaporins in the male excurrent duct. Biochim Biophys Acta. 2006;1758(8):1025-33 - PMID: 16935257 - DOI: 10.1016/j.bbamem.2006.06.026

  • Vallet M, Picard N, Loffing-Cueni D, Fysekidis M, Bloch-Faure M, Desch Pendrin regulation in mouse kidney primarily is chloride-dependent. J Am Soc Nephrol. 2006;17(8):2153-63 - PMID: 16825334 - DOI: 10.1681/ASN.2005101054

  • Pastor-Soler N, Pietrement C, Breton S Role of acid/base transporters in the male reproductive tract and potential consequences of their malfunction. 2005;20:417-28 - PMID: 16287991 - DOI: 10.1152/physiol.00036.2005

  • Miller RL, Zhang P, Smith M, Beaulieu V, Paunescu TG, Brown D, Breton S, Nelson RD V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice. Am J Physiol Cell Physiol. 2005;288(5):C1134-44 - PMID: 15634743 - DOI: 10.1152/ajpcell.00084.2004

  • Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005;288(6):F1103-12 - PMID: 15644488 - DOI: 10.1152/ajprenal.00337.2004

  • Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling. J Biol Chem. 2005;280(9):8452-63 - PMID: 15591047 - DOI: 10.1074/jbc.M412750200

  • Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. Proc Natl Acad Sci U S A. 2005;102(38):13616-21 - PMID: 16174750 - PMCID: PMC1224669 - DOI: 10.1073/pnas.0506769102

  • Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP Renal vacuolar H+-ATPase. 2004;84(4):1263-314 - PMID: 15383652 - DOI: 10.1152/physrev.00045.2003

  • Yeung CH, Breton S, Setiawan I, Xu Y, Lang F, Cooper TG Increased luminal pH in the epididymis of infertile c-ros knockout mice and the expression of sodium-hydrogen exchangers and vacuolar proton pump H+-ATPase. Mol Reprod Dev. 2004;68(2):159-68 - PMID: 15095336 - DOI: 10.1002/mrd.20067

  • Paunescu TG, Da Silva N, Marshansky V, McKee M, Breton S, Brown D Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis. Am J Physiol Cell Physiol. 2004;287(1):C149-62 - PMID: 15013950 - DOI: 10.1152/ajpcell.00464.2003

  • Wagner CA, L A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse. Pflug Arch Eur J Phy. 2003;446(5):623-32 - PMID: 12748863 - DOI: 10.1007/s00424-003-1082-3

  • Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003;278(49):49523-9 - PMID: 14512417 - PMCID: PMC3652382 - DOI: 10.1074/jbc.M309543200

  • Isnard-Bagnis C, Da Silva N, Beaulieu V, Yu AS, Brown D, Breton S Detection of ClC-3 and ClC-5 in epididymal epithelium: immunofluorescence and RT-PCR after LCM. Am J Physiol Cell Physiol. 2003;284(1):C220-32 - PMID: 12475763 - DOI: 10.1152/ajpcell.00374.2001

  • Zharkikh L, Zhu X, Stricklett PK, Kohan DE, Chipman G, Breton S, Brown D, Nelson RD Renal principal cell-specific expression of green fluorescent protein in transgenic mice. Am J Physiol Renal Physiol. 2002;283(6):F1351-64 - PMID: 12426236 - DOI: 10.1152/ajprenal.0224.2001

  • Pastor-Soler N, Isnard-Bagnis C, Herak-Kramberger C, Sabolic I, Van Hoek A, Brown D, Breton S Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens. Biol Reprod. 2002;66(6):1716-22 - PMID: 12021052 - DOI: 10.1095/biolreprod66.6.1716

  • Fisher JS, Pastor-Soler N, Sharpe RM, Breton S Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis. Biol Reprod. 2002;67(4):1106-14 - PMID: 12297525 - DOI: 10.1095/biolreprod67.4.1106

  • Breton S, Inoue T, Knepper MA, Brown D Antigen retrieval reveals widespread basolateral expression of syntaxin 3 in renal epithelia. Am J Physiol Renal Physiol. 2002;282(3):F523-9 - PMID: 11832435 - DOI: 10.1152/ajprenal.00128.2001

  • Breton S The cellular physiology of carbonic anhydrases. JOP. 2001;2(4 Suppl):159-64 - PMID: 11875253

  • Pastor-Soler N, Bagnis C, Sabolic I, Tyszkowski R, McKee M, Van Hoek A, Breton S, Brown D Aquaporin 9 expression along the male reproductive tract. Biol Reprod. 2001;65(2):384-93 - PMID: 11466204 - DOI: 10.1095/biolreprod65.2.384

  • Herak-Kramberger CM, Breton S, Brown D, Kraus O, Sabolic I Distribution of the vacuolar H+ atpase along the rat and human male reproductive tract. Biol Reprod. 2001;64(6):1699-707 - PMID: 11369598 - DOI: 10.1095/biolreprod64.6.1699

  • Bagnis C, Marsolais M, Biemesderfer D, Laprade R, Breton S Na+/H+-exchange activity and immunolocalization of NHE3 in rat epididymis. Am J Physiol Renal Physiol. 2001;280(3):F426-36 - PMID: 11181404 - DOI: 10.1152/ajprenal.2001.280.3.F426

  • Bagnis C, Marshansky V, Breton S, Brown D Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition. Am J Physiol Renal Physiol. 2001;280(3):F437-48 - PMID: 11181405 - DOI: 10.1152/ajprenal.2001.280.3.F437

  • Brown D, Breton S H(+)V-ATPase-dependent luminal acidification in the kidney collecting duct and the epididymis/vas deferens: vesicle recycling and transcytotic pathways. J Exp Biol. 2000;203(Pt 1):137-45 - PMID: 10600682

  • Brown D, Breton S Sorting proteins to their target membranes. Kidney Int. 2000;57(3):816-24 - PMID: 10720934 - DOI: 10.1046/j.1523-1755.2000.00920.x

  • Stevens AL, Breton S, Gustafson CE, Bouley R, Nelson RD, Kohan DE, Brown D Aquaporin 2 is a vasopressin-independent, constitutive apical membrane protein in rat vas deferens. Am J Physiol Cell Physiol. 2000;278(4):C791-802 - PMID: 10751327 - DOI: 10.1152/ajpcell.2000.278.4.C791

  • Silver RB, Breton S, Brown D Potassium depletion increases proton pump (H(+)-ATPase) activity in intercalated cells of cortical collecting duct. Am J Physiol Renal Physiol. 2000;279(1):F195-202 - PMID: 10894802 - DOI: 10.1152/ajprenal.2000.279.1.F195

  • Herak-Kramberger CM, Sabolić I, Blanusa M, Smith PJ, Brown D, Breton S Cadmium inhibits vacuolar H(+)ATPase-mediated acidification in the rat epididymis. Biol Reprod. 2000;63(2):599-606 - PMID: 10906070 - DOI: 10.1095/biolreprod63.2.599

  • Breton S, Wiederhold T, Marshansky V, Nsumu NN, Ramesh V, Brown D The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells. J Biol Chem. 2000;275(24):18219-24 - PMID: 10748165 - DOI: 10.1074/jbc.M909857199

  • Breton S, Nsumu NN, Galli T, Sabolic I, Smith PJ, Brown D Tetanus toxin-mediated cleavage of cellubrevin inhibits proton secretion in the male reproductive tract. Am J Physiol Renal Physiol. 2000;278(5):F717-25 - PMID: 10807583 - DOI: 10.1152/ajprenal.2000.278.5.F717

  • Bouley R, Breton S, Sun T, McLaughlin M, Nsumu NN, Lin HY, Ausiello DA, Brown D Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells. J Clin Invest. 2000;106(9):1115-26 - PMID: 11067864 - PMCID: PMC301414 - DOI: 10.1172/JCI9594

  • Shayakul C, Breton S, Brown D, Alper SL Gene therapy of inherited renal tubular disease. Am J Kidney Dis. 1999;34(2):374-9 - PMID: 10430991 - DOI: 10.1016/s0272-6386(99)70372-0

  • Sabolić I, Herak-Kramberger CM, Breton S, Brown D Na/K-ATPase in intercalated cells along the rat nephron revealed by antigen retrieval. J Am Soc Nephrol. 1999;10(5):913-22 - PMID: 10232676

  • Jensen LJ, Stuart-Tilley AK, Peters LL, Lux SE, Alper SL, Breton S Immunolocalization of AE2 anion exchanger in rat and mouse epididymis. Biol Reprod. 1999;61(4):973-80 - PMID: 10491632 - DOI: 10.1095/biolreprod61.4.973

  • Jensen LJ, Schmitt BM, Berger UV, Nsumu NN, Boron WF, Hediger MA, Brown D, Breton S Localization of sodium bicarbonate cotransporter (NBC) protein and messenger ribonucleic acid in rat epididymis. Biol Reprod. 1999;60(3):573-9 - PMID: 10026101 - DOI: 10.1095/biolreprod60.3.573

  • Breton S, Tyszkowski R, Sabolic I, Brown D Postnatal development of H+ ATPase (proton-pump)-rich cells in rat epididymis. Histochem Cell Biol. 1999;111(2):97-105 - PMID: 10090570 - DOI: 10.1007/s004180050339

  • Breton S, Hammar K, Smith PJS, Brown D Proton secretion in the male reproductive tract: involvement of Cl--independent HCO 3 - transport. Am J Physiol Cell Physiol. 1998;275(4):C1134-C1142 - PMID: 29585324 - DOI: 10.1152/ajpcell.1998.275.4.C1134

  • Brown D, Sabolic I, Breton S Polarized expression of membrane proteins in renal epithelial cells: involvement of specialized transport vesicles and intracellular pathways. Adv Nephrol Necker Hosp. 1998;27:297-315 - PMID: 9408453

  • Li C, Breton S, Morrison R, Cannon CL, Emma F, Sanchez-Olea R, Bear C, Strange K Recombinant pICln forms highly cation-selective channels when reconstituted into artificial and biological membranes. J Gen Physiol. 1998;112(6):727-36 - PMID: 9834142 - PMCID: PMC2229450 - DOI: 10.1085/jgp.112.6.727

  • Emma F, Breton S, Morrison R, Wright S, Strange K Effect of cell swelling on membrane and cytoplasmic distribution of pICln. Am J Physiol. 1998;274(6 Pt 1):C1545-51 - PMID: 9696697 - DOI: 10.1152/ajpcell.1998.274.6.C1545

  • Breton S, Lisanti MP, Tyszkowski R, McLaughlin M, Brown D Basolateral distribution of caveolin-1 in the kidney. Absence from H+-atpase-coated endocytic vesicles in intercalated cells. J Histochem Cytochem. 1998;46(2):205-14 - PMID: 9446827 - DOI: 10.1177/002215549804600209

  • Breton S, Hammar K, Smith PJ, Brown D Proton secretion in the male reproductive tract: involvement of Cl--independent HCO-3 transport. Am J Physiol. 1998;275(4 Pt 1):C1134-42 - PMID: 9755067 - DOI: 10.1152/ajpcell.1998.275.4.C1134

  • Breton S, Brown D Cold-induced microtubule disruption and relocalization of membrane proteins in kidney epithelial cells. J Am Soc Nephrol. 1998;9(2):155-66 - PMID: 9527391

  • Breton S, Smith PJS, Brown D Presence de cellules acidifiantes dans l'epididyme et le canal deferent: implication de la pompe a protons. Medecine/Sciences. 1997;13:57-61

  • Brown D, Smith PJ, Breton S Role of V-ATPase-rich cells in acidification of the male reproductive tract. J Exp Biol. 1997;200(Pt 2):257-62 - PMID: 9050233

  • Macri P, Breton S, Marsolais M, Lapointe J, Laprade R Hypertonicity decreases basolateral K+ and Cl- conductances in rabbit proximal convoluted tubule. J Membr Biol. 1997;155(3):229-37 - PMID: 9050446 - DOI: 10.1007/s002329900175

  • Brown D, Breton S Mitochondria-rich, proton-secreting epithelial cells. J Exp Biol. 1996;199(Pt 11):2345-58 - PMID: 9114500

  • Breton S, Smith PJ, Lui B, Brown D Acidification of the male reproductive tract by a proton pumping (H+)-ATPase. Nature Med. 1996;2(4):470-2 - PMID: 8597961 - DOI: 10.1038/nm0496-470

  • Breton S, Marsolais M, Lapointe JY, Laprade R Cell volume increases of physiologic amplitude activate basolateral K and CI conductances in the rabbit proximal convoluted tubule. J Am Soc Nephrol. 1996;7(10):2072-87 - PMID: 8915967

  • Breton S, Belachgar F, Marsolais M, Lapointe JY, Laprade R Inhibition of basolateral potassium conductance by taurine in the proximal convoluted tubule. Am J Physiol. 1996;271(5 Pt 2):F1012-9 - PMID: 8945995 - DOI: 10.1152/ajprenal.1996.271.5.F1012

  • Breton S, Marsolais M, Laprade R Hypotonicity increases basolateral taurine permeability in rabbit proximal convoluted tubule. Am J Physiol. 1995;268(4 Pt 2):F595-603 - PMID: 7733316 - DOI: 10.1152/ajprenal.1995.268.4.F595

  • Breton S, Alper SL, Gluck SL, Sly WS, Barker JE, Brown D Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice. Am J Physiol. 1995;269(6 Pt 2):F761-74 - PMID: 8594870 - DOI: 10.1152/ajprenal.1995.269.6.F761

  • Beck JS, Marsolais M, N Dibutyryl cyclic adenosine monophosphate stimulates the sodium pump in rabbit renal cortical tubules. Ren Physiol Biochem. 1995;18(1):21-6 - PMID: 7533315 - DOI: 10.1159/000173895

  • Breton S, Beck JS, Laprade R cAMP stimulates proximal convoluted tubule Na(+)-K(+)-ATPase activity. Am J Physiol. 1994;266(3 Pt 2):F400-10 - PMID: 8160788 - DOI: 10.1152/ajprenal.1994.266.3.F400

  • Macri P, Breton S, Beck JS, Cardinal J, Laprade R Basolateral K+, Cl-, and HCO3- conductances and cell volume regulation in rabbit PCT. Am J Physiol. 1993;264(2 Pt 2):F365-76 - PMID: 8447445 - DOI: 10.1152/ajprenal.1993.264.2.F365

  • Breton S, Beck JS, Cardinal J, Giebisch G, Laprade R Involvement and source of calcium in volume regulatory decrease of collapsed proximal convoluted tubule. Am J Physiol. 1992;263(4 Pt 2):F656-64 - PMID: 1415737 - DOI: 10.1152/ajprenal.1992.263.4.F656

  • Beck JS, Breton S, Giebisch G, Laprade R Potassium conductance regulation by pH during volume regulation in rabbit proximal convoluted tubules. Am J Physiol. 1992;263(3 Pt 2):F453-8 - PMID: 1415573 - DOI: 10.1152/ajprenal.1992.263.3.F453

  • Maenz DD, Chenu C, Breton S, Berteloot A pH-dependent heterogeneity of acidic amino acid transport in rabbit jejunal brush border membrane vesicles. J Biol Chem. 1992;267(3):1510-6 - PMID: 1346136

  • Laprade R, Lapointe JY, Breton S, Duplain M, Cardinal J Intracellular potassium activity in mammalian proximal tubule: effect of perturbations in transepithelial sodium transport. J Membr Biol. 1991;121(3):249-59 - PMID: 1865489 - DOI: 10.1007/bf01951558

  • Berteloot A, Malo C, Breton S, Brunette M Fast sampling, rapid filtration apparatus: principal characteristics and validation from studies of D-glucose transport in human jejunal brush-border membrane vesicles. J Membr Biol. 1991;122(2):111-25 - PMID: 1895337 - DOI: 10.1007/bf01872635

  • Beck JS, Breton S, Mairb Relationship between sodium transport and intracellular ATP in isolated perfused rabbit proximal convoluted tubule. Am J Physiol. 1991;261(4 Pt 2):F634-9 - PMID: 1928376 - DOI: 10.1152/ajprenal.1991.261.4.F634

  • Beck JS, Breton S, Laprade R, Giebisch G Volume regulation and intracellular calcium in the rabbit proximal convoluted tubule. Am J Physiol. 1991;260(6 Pt 2):F861-7 - PMID: 2058707 - DOI: 10.1152/ajprenal.1991.260.6.F861