Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy
Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cell.
J Am Chem Soc. 2012;134(45):18499-18502 - PMID: 23092113 - PMCID: PMC3498844 - DOI: 10.1021/ja307689w
Mechanism of Magnetic Relaxation Switching Sensing.
Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing.
Over a hump for imaging atherosclerosis: nanobodies visualize vascular cell adhesion molecule-1 in inflamed plaque.
Circ Res. 2012;110(7):902-3 - PMID: 22461358 - DOI: 10.1161/CIRCRESAHA.112.267260
A Magnetic Gram Stain for Bacterial Detection.
Angew Chem Int Ed Engl. 2012;51(31):7752-5 - PMID: 22744868 - PMCID: PMC3496380 - DOI: 10.1002/anie.201202982
Bioorthogonal Imaging of Aurora Kinase A in Live Cells.
Angew Chem Int Ed Engl. 2012;51(27):6598-603 - PMID: 22644700 - PMCID: PMC3523717 - DOI: 10.1002/anie.201200994
Synthesis of [(18) F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging.
Angew Chem Int Ed Engl. 2012;51(19):4603-6 - PMID: 22473535 - PMCID: PMC3343182 - DOI: 10.1002/anie.201107957
Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence.
JACC Cardiovasc Imaging. 2012;5(6):607-15 - PMID: 22698530 - PMCID: PMC3376390 - DOI: 10.1016/j.jcmg.2012.01.017
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.
Proc Natl Acad Sci U S A. 2012;109(52):21444-9 - PMID: 23236189 - PMCID: PMC3535589 - DOI: 10.1073/pnas.1217972110
Reactive polymer enables efficient in vivo bioorthogonal chemistry.
Proc Natl Acad Sci U S A. 2012;109(13):4762-7 - PMID: 22411831 - PMCID: PMC3324005 - DOI: 10.1073/pnas.1113466109
Magnetic Nanoparticles and microNMR for Diagnostic Applications.
Cell Sorting: Microfluidic Cell Sorter (μFCS) for On-chip Capture and Analysis of Single Cells
Adv Healthc Mater. 2012;1(4):432-6 - PMID: 23184773 - PMCID: PMC3508764 - DOI: 10.1002/adhm.201200046
Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation.
Dual Imaging and Photoactivated Nanoprobe for Controlled Cell Tracking.
On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics.
Inflammation Modulates Murine Venous Thrombosis Resolution In Vivo: Assessment by Multimodal Fluorescence Molecular Imaging.
Arterioscler Thromb Vasc Biol. 2012;32(11):2616-24 - PMID: 22995524 - PMCID: PMC3516622 - DOI: 10.1161/ATVBAHA.112.251983
Sensitive and Direct Detection of Circulating Tumor Cells by Multimarker µ-Nuclear Magnetic Resonance.
Imaging Therapeutic PARP Inhibition In Vivo through Bioorthogonally Developed Companion Imaging Agents
Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity.
ACS Chem Biol. 2012;7(9):1520-8 - PMID: 22724584 - DOI: 10.1021/cb300235m
meso-Arylporpholactones and their Reduction Products.
Crebinostat: A Novel cognitive enhancer that inhibits Histone Deacetylase activity and Modulates Chromatin-mediated Neuroplasticity.
Neuropharmacology. 2012;64(1):81-96 - PMID: 22771460 - PMCID: PMC3447535 - DOI: 10.1016/j.neuropharm.2012.06.043
Characterization of Plasmodium Liver Stage Inhibition by Halofuginone.
Efficient (18)F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells.
Detection and treatment of intravascular thrombi with magnetofluorescent nanoparticles.
Method Enzymol. 2012;508:191-209 - PMID: 22449927 - DOI: 10.1016/B978-0-12-391860-4.00010-0
Multicore Assemblies Potentiate Magnetic Properties of Biomagnetic Nanoparticles.
Multiplexed Magnetic Labeling Amplification Using Oligonucleotide Hybridization.
Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy.
Biomedical Applications of Tetrazine Cycloadditions.
The effect of selective inhibition of HDAC6 with ACY1215 on bortezomib activity in multiple myeloma (MM).
J Clin Oncol. 2011;29(15_suppl):e18569 - PMID: 28023028
Synapse microarray identification of small molecules that enhance synaptogenesis.
Helimeric Porphyrinoids: Stereostructure and Chiral Resolution of meso-Tetraarylmorpholinochlorins.
J Am Chem Soc. 2011;133(22):8740-8752 - PMID: 21534626 - DOI: 10.1021/ja202451t
Ubiquitous Detection of Gram-Positive Bacteria with Bioorthogonal Magnetofluorescent Nanoparticles.
Nanoparticle Mediated Measurement of Target-Drug Binding in Cancer Cells.
Probing Intracellular Biomarkers and Mediators of Cell Activation Using Nanosensors and Bioorthogonal Chemistry.
Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi-Target Imaging.
Angew Chem Int Ed Engl. 2011;51(4):920-2 - PMID: 22162316 - PMCID: PMC3304098 - DOI: 10.1002/anie.201104389
Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers.
Angew Chem Int Ed Engl. 2011;51(2):450-4 - PMID: 22113923 - PMCID: PMC3309171 - DOI: 10.1002/anie.201105670
Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification.
Angew Chem Int Ed Engl. 2011;50(40):9378-81 - PMID: 21948435 - PMCID: PMC3187564 - DOI: 10.1002/anie.201103273
Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.
Angew Chem Int Ed Engl. 2011;50(20):4663-6 - PMID: 21495138 - PMCID: PMC3334859 - DOI: 10.1002/anie.201100101
Synthesis and In Vivo Imaging of a (18) F-Labeled PARP1 Inhibitor Using a Chemically Orthogonal Scavenger-Assisted High-Performance Method.
Angew Chem Int Ed Engl. 2011;50(8):1922-5 - PMID: 21328671 - PMCID: PMC3471140 - DOI: 10.1002/anie.201006579
Accurate measurement of pancreatic islet {beta}-cell mass using a second-generation fluorescent exendin-4 analog.
Proc Natl Acad Sci U S A. 2011;108(31):12815-20 - PMID: 21768367 - PMCID: PMC3150928 - DOI: 10.1073/pnas.1109859108
In Vivo PET-imaging of Histone Deacetylases by 18F-Suberoylanilide Hydroxamic Acid (18F-SAHA).
Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc(1) Inhibitors.
Chem Biol. 2011;18(12):1602-10 - PMID: 22195562 - PMCID: PMC3474356 - DOI: 10.1016/j.chembiol.2011.09.016
The role of nanomedicine in the imaging and therapy of thrombosis.
Nanomedicine (Lond). 2011;6(8):1291-3 - PMID: 22026372 - PMCID: PMC3332076 - DOI: 10.2217/nnm.11.128
Facile Synthesis of Monofunctional Pentamethine Carbocyanine Fluorophores.
Dyes Pigm. 2011;90(2):119-122 - PMID: 21475610 - PMCID: PMC3070263 - DOI: 10.1016/j.dyepig.2010.12.008
Specific Pathogen Detection Using Bioorthogonal Chemistry and Diagnostic Magnetic Resonance.
89Zr Labeled Dextran Nanoparticles Enable in vivo Macrophage Imaging.
Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation.
A Modular Strategy for the Construction of Radiometallated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels-Alder Click Chemistry.
High-Yielding, Two-Step (18) F Labeling Strategy for (18) F-PARP1 Inhibitors.
Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.
Leuk Lymphoma. 2011;52(8):1544-55 - PMID: 21699378 - PMCID: PMC4113006 - DOI: 10.3109/10428194.2011.570821
Microarray profiling reveals the Integrated Stress Response is activated by Halofuginone in mammary epithelial cells.
Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection
Quantitative Nanostructure-Activity Relationship Modeling.
Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells.
Angew Chem Int Ed Engl. 2010;19 (49):2869-2872 - PMID: 20306505 - PMCID: PMC3433403 - DOI: 10.1002/anie.200906120
Multifunctional agents for concurrent imaging and therapy in cardiovascular disease.
Adv Drug Deliv Rev. 2010;62(11):1023-30 - PMID: 20654664 - PMCID: PMC2974776 - DOI: 10.1016/j.addr.2010.07.004
Chemical phylogenetics of histone deacetylases.
A Light-Activated Theranostic Nanoagent for Targeted Macrophage Ablation in Inflammatory Atherosclerosis.
Targeted nanoagents for the detection of cancers.
Mol Oncol. 2010;4(6):511-28 - PMID: 20851695 - PMCID: PMC2981649 - DOI: 10.1016/j.molonc.2010.08.003
A Concise Silylamine Approach to 2-Amino-3-hydroxy-indoles with Potent in vivo Antimalaria Activity.
Binding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles
Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.
On the inhibition of histone deacetylase 8.
Bioorg Med Chem. 2010;18(11):4103-4110 - PMID: 20472442 - PMCID: PMC3245874 - DOI: 10.1016/j.bmc.2010.03.080
Magnetic nanoparticles for biomedical NMR-based diagnostics
Beilstein J Nanotechnol. 2010;1:142154 - PMID: 21977404 - PMCID: PMC3045933 - DOI: 10.3762/bjnano.1.17
Nanoparticle-Target Interactions Parallel Antibody-Protein Interactions.
Multimodal Nanoagents for the Detection of Intravascular Thrombi.
A screening paradigm for the design of improved polymer-coated superparamagnetic iron oxide nanoparticles
J Mater Chem. 2009;19:6387-6392
High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model.
Labels and probes for live cell imaging: overview and selection guide.
Methods Mol Biol. 2009;591:17-45 - PMID: 19957122 - DOI: 10.1007/978-1-60761-404-3_2
One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes.
Tetrahedron Lett. 2007;48(25):4383-4385 - PMID: 19834587 - PMCID: PMC2761723 - DOI: 10.1016/j.tetlet.2007.04.088
Chemical and Genetic Sensors in Biomedical Research.
J Biomed Opt. 2005;10(4):41201 - PMID: 23171967
Magnetic Nanosensors for the Detection of Oligonucleotide Sequences.
Angew Chem Int Ed Engl. 2001;40(17):3204-3206 - PMID: 29712059 - DOI: 10.1002/1521-3773(20010903)40:17<3204::AID-ANIE3204>3.0.CO;2-H
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