Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.
Nat Med. 2014;20(11):1301-9 - PMID: 25344738 - DOI: 10.1038/nm.3708
Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.
Science. 2014;344(6190):1396-401 - PMID: 24925914 - PMCID: PMC4123637 - DOI: 10.1126/science.1254257
Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
Discovery of biomarkers predictive of GSI response in triple negative breast cancer and adenoid cystic carcinoma.
Cancer Discov. 2014;4(10):1154-67 - PMID: 25104330 - PMCID: PMC4184927 - DOI: 10.1158/2159-8290.CD-13-0830
Imaging macrophages with nanoparticles.
Nat Mater. 2014;13(2):125-38 - PMID: 24452356 - DOI: 10.1038/nmat3780
EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma.
Cancer Cell. 2014;26(5):668-81 - PMID: 25453903 - PMCID: PMC4492343 - DOI: 10.1016/j.ccell.2014.10.004
Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.
In vivo imaging of specific drug-target binding at subcellular resolution.
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin
Sci Transl Med. 2014;6 (261):261ra152 - PMID: 25378644 - PMCID: PMC4330962 - DOI: 10.1126/scitranslmed.3009318
Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates
Sci Transl Med. 2014;6(219):219ra9 - PMID: 24431113 - PMCID: PMC4063286 - DOI: 10.1126/scitranslmed.3007361
Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.
Clin Cancer Res. 2014;21(2):396-404 - PMID: 25348516 - PMCID: PMC4447091 - DOI: 10.1158/1078-0432.CCR-14-1591
A novel Bruton's tyrosine kinase inhibitor CC-292 in combination with the proteasome inhibitor carfilzomib impacts the bone microenvironment in a multiple myeloma model with resultant antimyeloma activity.
Leukemia. 2014;28(9):1892-901 - PMID: 24518207 - DOI: 10.1038/leu.2014.69
Gut microbiome and anticancer immune response: really hot Sh*t!
Cell Death Differ. 2014;22(2):199-214 - PMID: 24832470 - PMCID: PMC4291500 - DOI: 10.1038/cdd.2014.56
Immune-dependent antineoplastic effects of cisplatin plus pyridoxine in non-small-cell lung cancer.
Oncogene. 2014;34(23):3053-62 - PMID: 25065595 - DOI: 10.1038/onc.2014.234
Serum Inflammatory Markers and Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases.
Clin Gastroenterol Hepatol. 2014;12(8):1342-1348.e1 - PMID: 24407106 - PMCID: PMC4085150 - DOI: 10.1016/j.cgh.2013.12.030
Enhanced primary tumor delineation in pancreatic adenocarcinoma using ultrasmall super paramagnetic iron oxide nanoparticle-ferumoxytol: an initial experience with histopathologic correlation.
Mortality and extraintestinal cancers in patients with primary sclerosing cholangitis and inflammatory bowel disease.
J Crohns Colitis. 2014;8(9):956-63 - PMID: 24559536 - PMCID: PMC4136996 - DOI: 10.1016/j.crohns.2014.01.019
Platinum Compounds for High-Resolution In Vivo Cancer Imaging.
Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis.
Acquired Resistance to Crizotinib from a Mutation in CD74-ROS1.
N Engl J Med. 2013;368(25):2395-401 - PMID: 23724914 - PMCID: PMC3878821 - DOI: 10.1056/NEJMoa1215530
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.
Epigenetic reprogramming in cancer.
Angiotensin II Drives the Production of Tumor-Promoting Macrophages
Immunity. 2013;38(2):296-308 - PMID: 23333075 - PMCID: PMC3582771 - DOI: 10.1016/j.immuni.2012.10.015
Differential regulation of myeloid leukemias by the bone marrow microenvironment.
Therapeutically reeducating macrophages to treat GBM.
Nature Med. 2013;19(10):1207-1208 - PMID: 24100977 - DOI: 10.1038/nm.3355
In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling.
Nanoparticles for cancer imaging: The good, the bad, and the promise.
Nano Today. 2013;8(5):454-460 - PMID: 25419228 - PMCID: PMC4240321 - DOI: 10.1016/j.nantod.2013.06.001
Molecular Pathways: Tumor-derived microvesicles and their interactions with immune cells in vivo.
Clin Cancer Res. 2013;19(10):2598-604 - PMID: 23426276 - PMCID: PMC3655093 - DOI: 10.1158/1078-0432.CCR-12-0962
Induction of differential apoptotic pathways in multiple myeloma cells by class selective histone deacetylase inhibitors.
Histone deacetylase 3 (HDAC3) as a novel therapeutic target in multiple myeloma.
MicroRNA-mediated control of macrophages and its implications for cancer.
Trends Immunol. 2013;34(7):350-9 - PMID: 23498847 - PMCID: PMC3700601 - DOI: 10.1016/j.it.2013.02.003
Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1.
Cancer Res. 2013;74(3):738-50 - PMID: 24310399 - PMCID: PMC3928601 - DOI: 10.1158/0008-5472.CAN-13-2650
An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma.
Cell Rep. 2013;3(5):1567-1579 - PMID: 23707066 - PMCID: PMC3774301 - DOI: 10.1016/j.celrep.2013.04.021
Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance.
Nanomedicine. 2013;10 :661-668 - PMID: 24200523 - PMCID: PMC3966960 - DOI: 10.1016/j.nano.2013.10.008
Mapping patterns of nodal metastases in seminoma: Rethinking radiotherapy fields.
Radiother Oncol. 2013;106(1):64-8 - PMID: 23321493 - DOI: 10.1016/j.radonc.2012.12.002
Association Between Reduced Plasma 25-hydroxy Vitamin D and Increased Risk of Cancer in Patients with Inflammatory Bowel Diseases.
Clin Gastroenterol Hepatol. 2013;12(5):821-7 - PMID: 24161349 - PMCID: PMC3995841 - DOI: 10.1016/j.cgh.2013.10.011
Targeting cathepsin e in pancreatic cancer by a small molecule allows in vivo detection.
Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and miniaturized micro-NMR system.
Nanomedicine (Lond). 2013;9(7):1009-17 - PMID: 23570873 - PMCID: PMC4330975 - DOI: 10.1016/j.nano.2013.03.011
Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip
Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle.
Imaging Behavior of the Normal Adrenal on Ferumoxytol-Enhanced MRI: Preliminary Findings.
AJR Am J Roentgenol. 2013;201(1):117-21 - PMID: 23789664 - DOI: 10.2214/AJR.12.9357
ACR Appropriateness Criteria Staging and Follow-up of Ovarian Cancer.
J Am Coll Radiol. 2013;10(11):822-7 - PMID: 24183551 - DOI: 10.1016/j.jacr.2013.07.017
Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer.
Automated analysis of clonal cancer cells by intravital imaging.
Remote control of macrophage production by cancer.
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism.
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism.
Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy
Hypoxia promotes dissemination of multiple myeloma through acquisition of endothelial to mesenchymal transition-like features.
Blood. 2012;119(24):5782-94 - PMID: 22394600 - PMCID: PMC3382938 - DOI: 10.1182/blood-2011-09-380410
ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression.
Cancer Cell. 2012;22(2):180-93 - PMID: 22897849 - PMCID: PMC3422511 - DOI: 10.1016/j.ccr.2012.06.032
Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector
Sci Transl Med. 2012;4 (141):141ra92 - PMID: 22764208 - PMCID: PMC3603277 - DOI: 10.1126/scitranslmed.3003747
Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing.
Implantable microenvironments to attract hematopoietic stem/cancer cells.
Proc Natl Acad Sci U S A. 2012;109(48):19638-43 - PMID: 23150542 - PMCID: PMC3511730 - DOI: 10.1073/pnas.1208384109
Origins of tumor-associated macrophages and neutrophils.
Proc Natl Acad Sci U S A. 2012;109(7):2491-6 - PMID: 22308361 - PMCID: PMC3289379 - DOI: 10.1073/pnas.1113744109
Cell Sorting: Microfluidic Cell Sorter (μFCS) for On-chip Capture and Analysis of Single Cells
Adv Healthc Mater. 2012;1(4):432-6 - PMID: 23184773 - PMCID: PMC3508764 - DOI: 10.1002/adhm.201200046
A Blueprint for an International Cancer Epigenome Consortium. A Report from the AACR Cancer Epigenome Task Force.
Cancer Res. 2012;72(24):6319-6324 - PMID: 23188507 - DOI: 10.1158/0008-5472.CAN-12-3658
In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single cell resolution.
Cancer Res. 2012;72(12):2949-56 - PMID: 22505651 - PMCID: PMC3603290 - DOI: 10.1158/0008-5472.CAN-11-4096
Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation.
Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators.
CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy.
J Neurooncol. 2012;110(1):37-48 - PMID: 22875706 - PMCID: PMC4291475 - DOI: 10.1007/s11060-012-0948-7
Incidental findings at initial imaging workup of patients with prostate cancer: clinical significance and outcomes.
AJR Am J Roentgenol. 2012;199(6):1305-11 - PMID: 23169722 - DOI: 10.2214/AJR.11.8417
Establishment and characterization of a novel chordoma cell line: CH22.
J Orthop Res. 2012;30(10):1666-73 - PMID: 22504929 - DOI: 10.1002/jor.22113
Pelvic nodal imaging.
Radiol Clin North Am. 2012;50(6):1111-25 - PMID: 23122041 - DOI: 10.1016/j.rcl.2012.08.002
Defining the role of TORC1 and TORC2 in multiple myeloma.
Blood. 2011;118(26):6860-70 - PMID: 22045983 - PMCID: PMC3245208 - DOI: 10.1182/blood-2011-03-342394
Differential niche and Wnt requirements during acute myeloid leukemia progression.
Blood. 2011;118(10):2849-56 - PMID: 21765021 - PMCID: PMC3172801 - DOI: 10.1182/blood-2011-03-345165
Utility of preoperative ferumoxtran-10 enhanced MRI to evaluate retroperitoneal lymph node metastasis in advanced cervical cancer: Results of ACRIN 6671/GOG 0233.
J Clin Oncol. 2011;29(15_suppl):5035 - PMID: 28023716
MRI prior to systematic lymphadenectomy in patients with locally advanced cervical cancer.
J Clin Oncol. 2011;29(15_suppl):5042 - PMID: 28023697
Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples
Sci Transl Med. 2011;3(71):71ra16 - PMID: 21346169 - PMCID: PMC3086073 - DOI: 10.1126/scitranslmed.3002048
Nanoparticle Mediated Measurement of Target-Drug Binding in Cancer Cells.
Analysis of Mitosis and Antimitotic Drug Responses in Tumors by In Vivo Microscopy and Single-Cell Pharmacodynamics.
Cancer Res. 2011;71(13):4608-16 - PMID: 21712408 - PMCID: PMC3129392 - DOI: 10.1158/0008-5472.CAN-11-0412
Bevacizumab With Angiostatin-armed oHSV Increases Antiangiogenesis and Decreases Bevacizumab-induced Invasion in U87 Glioma.
In Vivo PET-imaging of Histone Deacetylases by 18F-Suberoylanilide Hydroxamic Acid (18F-SAHA).
Interview: Nanomedicine in oncology: miniaturized means to an enormous end.
Nanomedicine (Lond). 2011;6(9):1495-8 - PMID: 22077461 - DOI: 10.2217/nnm.11.138
Monocytes link atherosclerosis and cancer.
Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer
J Nanomedic Nanotechnol. 2011;2(4):112 - PMID: 22319675 - PMCID: PMC3273319 - DOI: 10.4172/2157-7439.1000112
Advanced cross-sectional imaging techniques for the detection and characterization of renal masses
Imaging Med. 2011;3 (2):207-218
Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection
In Vivo Imaging in Cancer.
Cold Spring Harb Perspect Biol. 2010;2(12):a003848 - PMID: 20861158 - PMCID: PMC2982169 - DOI: 10.1101/cshperspect.a003848
Hybrid PET-optical imaging using targeted probes
Proc Natl Acad Sci U S A. 2010;107(17):7910-5 - PMID: 20385821 - PMCID: PMC2867879 - DOI: 10.1073/pnas.0915163107
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.
Proc Natl Acad Sci U S A. 2010;107(11):5124-9 - PMID: 20194748 - PMCID: PMC2841922 - DOI: 10.1073/pnas.0911929107
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.
Proc Natl Acad Sci U S A. 2010;107(4):1565-70 - PMID: 20080688 - PMCID: PMC2824379 - DOI: 10.1073/pnas.0908682107
The Phosphoinositide 3-Kinase Regulatory Subunit p85{alpha} Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling.
Cancer Res. 2010;70(13):5305-5315 - PMID: 20530665 - PMCID: PMC3204358 - DOI: 10.1158/0008-5472.CAN-09-3399
Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors.
Imaging Primary Lung Cancers in Mice to Study Radiation Biology.
Int J Radiat Oncol Biol Phys. 2010;76(4):973-977 - PMID: 20206017 - PMCID: PMC2847457 - DOI: 10.1016/j.ijrobp.2009.11.038
Targeted nanoagents for the detection of cancers.
Mol Oncol. 2010;4(6):511-28 - PMID: 20851695 - PMCID: PMC2981649 - DOI: 10.1016/j.molonc.2010.08.003
Detection of lymph nodes in pelvic malignancies with computed tomography and magnetic resonance imaging.
Clin Imaging. 2010;34(5):361-6 - PMID: 20813300 - DOI: 10.1016/j.clinimag.2009.07.004
Rapid detection and profiling of cancer cells in fine-needle aspirates.
Proc Natl Acad Sci U S A. 2009;106 (30):12459-12464 - PMID: 19620715 - PMCID: PMC2718371 - DOI: 10.1073/pnas.0902365106
Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy.
Proc Natl Acad Sci U S A. 2009;106(12):4822-7 - PMID: 19264968 - PMCID: PMC2660771 - DOI: 10.1073/pnas.0806647106
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.
Proc Natl Acad Sci U S A. 2009;106(8):2712-6 - PMID: 19196966 - PMCID: PMC2650331 - DOI: 10.1073/pnas.0813314106
Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle
Mutant Sodium Channel for Tumor Therapy.
Behavior of immune players in the tumor microenvironment.
Curr Opin Oncol. 2009;21(1):53-9 - PMID: 19125019 - PMCID: PMC2901856 - DOI: 10.1097/CCO.0b013e32831bc38a
Genetically engineered T cells to target EGFRvIII expressing glioblastoma.
J Neuro-Oncol. 2009;94(3):373-82 - PMID: 19387557 - PMCID: PMC2730985 - DOI: 10.1007/s11060-009-9889-1
Overview of nanoparticle use in cancer imaging.
Cancer Biomark. 2009;5:61-7 - PMID: 19414922 - DOI: 10.3233/CBM-2009-0578
Imaging in the era of molecular oncology
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma.
BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.
Restoration of p53 function leads to tumour regression in vivo.
Nature. 2007;445:661-5 - PMID: 17251932 - DOI: 10.1038/nature05541
A spatially and temporally restricted mouse model of soft tissue sarcoma.
Nature Med. 2007;13(8):992-997 - PMID: 17676052 - DOI: 10.1038/nm1602
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
Proc Natl Acad Sci U S A. 2007;104:12457-12461 - PMID: 17640914 - PMCID: PMC1941490 - DOI: 10.1073/pnas.0704460104
Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy
J Natl Cancer Inst. 2007;(99) 23:1768-1781 - PMID: 18042934 - DOI: 10.1093/jnci/djm229
Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo
Cancer Res. 2007;67 (15):7335-7342 - PMID: 17671203 - DOI: 10.1158/0008-5472.CAN-07-0077
Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment.
Int J Cancer. 2007;(121) 11:2492-2500 - PMID: 17683072 - DOI: 10.1002/ijc.22995
Molecular Imaging in Cancer
Science. 2006;312:1168-1171 - PMID: 16728630 - DOI: 10.1126/science.1125949
Fluorescent Nanoparticle Uptake for Brain Tumor Visualization
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