Breton

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Breton, Sylvie, PhD

Sylvie_breton
Phone: 617-643-3182, 617-726-5785
Email: Breton.Sylvie@mgh.harvard.edu

Research

Sylvie Breton is a PhD in Biophysics who specializes in the cell biology of membrane transport. She studies luminal acidification and intercellular communication networks in the kidney and epididymis. She became Professor of Medicine at Harvard Medical School in 2012, and she has been at MGH since 1994.

Selected Publications (from total of 115)

Menezes TP, Hill E, de Alencar Moura A, Lobo MDP, Monteiro-Moreira ACO, Breton S, Machado-Neves M
Pattern of protein expression in the epididymis of Oligoryzomys nigripes (Cricetidae, Sigmodontinae).
Cell Tissue Res. 2017;:ePub - PMID: 29119327
Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA
Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq.
Proc Natl Acad Sci U S A. 2017;114(46):E9989-E9998 - PMID: 29089413
Park YJ, Battistone MA, Kim B, Breton S
Relative contribution of clear cells and principal cells to luminal pH in the mouse epididymis.
Biol Reprod. 2017;96(2):366-375 - PMID: 28203710
Castro MM, Kim B, Hill E, Fialho MC, Puga LC, Freitas MB, Breton S, Machado-Neves M
The expression patterns of aquaporin 9, vacuolar H(+)-ATPase, and cytokeratin 5 in the epididymis of the common vampire bat.
Histochem Cell Biol. 2016;147(1):39-48 - PMID: 27549752
Cotter K, Liberman R, Sun-Wada G, Wada Y, Sgroi D, Naber S, Brown D, Breton S, Forgac M
The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer.
Oncotarget. 2016;7(29):46142-46157 - PMID: 27323815 - PMCID: PMC5216787
Roy J*, Kim B*, Hill E, Visconti P, Krapf D, Vinegoni C, Weissleder R, Brown D, Breton S
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.
Nat Commun. 2016;7:10666 - PMID: 26868824 - PMCID: PMC4754344
Kim B, Breton S
The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis.
Biol Reprod. 2015;94(1):22 - PMID: 26658708 - PMCID: PMC4809559
Breton S, Ruan YC, Park YJ, Kim B
Regulation of epithelial function, differentiation, and remodeling in the epididymis.
Asian J Androl. 2015;18(1):3-9 - PMID: 26585699 - PMCID: PMC4736353
Merkulova M, Păunescu TG, Azroyan A, Marshansky V, Breton S, Brown D
Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.
Sci Rep. 2015;5:14827 - PMID: 26442671 - PMCID: PMC4595830
Kim B, Breton S
Localization of the gap junction protein, connexin 43, and E-cadherin/Cadherin-1 in the proximal mouse epididymis.
Mol Reprod Dev. 2015;82(10):723 - PMID: 26331361
Azroyan A, Cortez-Retamozo V, Bouley R, Liberman R, Ruan YC, Kiselev E, Jacobson KA, Pittet MJ, Brown D, Breton S
Renal Intercalated Cells Sense and Mediate Inflammation via the P2Y14 Receptor.
PLoS ONE. 2015;10(3):e0121419 - PMID: 25799465 - PMCID: PMC4370445
Kim B, Roy J, Shum WW, Da Silva N, Breton S
Role of Testicular Luminal Factors on Basal Cell Elongation and Proliferation in the Mouse Epididymis.
Biol Reprod. 2014;92(1):9 - PMID: 25411392 - PMCID: PMC4434934
Ruan YC, Wang Y, Da Silva N, Kim B, Diao RY, Hill E, Brown D, Chan HC, Breton S
CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation via the ZONAB pathway.
J Cell Sci. 2014;127(Pt 20):4396-408 - PMID: 25107366 - PMCID: PMC4197086 - Cover
Păunescu TG, Shum WW, Huynh C, Lechner L, Goetze B, Brown D, Breton S
High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa.
Mol Hum Reprod. 2014;20(10):929-37 - PMID: 25015675 - PMCID: PMC4172170
Jun HJ, Roy J, Smith TB, Wood LB, Lane K, Woolfenden S, Punko D, Bronson RT, Haigis KM, Breton S, Charest A
ROS1 Signaling Regulates Epithelial Differentiation in the Epididymis.
Endocrinology. 2014;:en20141341 - PMID: 24971615 - PMCID: PMC4138574
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