Breton, Sylvie, PhD
Sylvie Breton is a PhD in Biophysics who specializes in the cell biology of membrane transport, using a multidisciplinary approach including high-resolution laser scanning confocal microscopy, 3D reconstructions of single cells, and electrophysiological techniques. She studies luminal acidification, and water and solute transport in the male reproductive tract. She became Professor of Medicine at Harvard Medical School in 2012, and she has been at MGH since 1994.
Selected Publications (from total of 104)
Role of Testicular Luminal Factors on Basal Cell Elongation and Proliferation in the Mouse Epididymis.
Biol Reprod. 2014;92(1):9 - PMID: 25411392
CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation via the ZONAB pathway.
High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa.
ROS1 Signaling Regulates Epithelial Differentiation in the Epididymis.
Epithelial Basal Cells Are Distinct from Dendritic Cells and Macrophages in the Mouse Epididymis.
Dedifferentiation of committed epithelial cells into stem cells in vivo.
Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells.
Regulation of Luminal Acidification by the V-ATPase.
Plasticity of basal cells during postnatal development in the rat epididymis.
Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymis.
Altered V-ATPase expression in renal intercalated cells isolated from B1-subunit deficient mice by fluorescence activated cell sorting.
In vivo imaging of tracheal epithelial cells in mice during airway regeneration.
cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit.
ATP secretion in the male reproductive tract: essential role of CFTR.
Large-Scale Phenotyping of an Accurate Genetic Mouse Model of JNCL Identifies Novel Early Pathology Outside the Central Nervous System.