Breton, Sylvie, PhD
Sylvie Breton is a PhD in Biophysics who specializes in the cell biology of membrane transport, using a multidisciplinary approach including high-resolution laser scanning confocal microscopy, 3D reconstructions of single cells, and electrophysiological techniques. She studies luminal acidification, and water and solute transport in the male reproductive tract. She became Professor of Medicine at Harvard Medical School in 2012, and she has been at MGH since 1994.
Selected Publications (from total of 109)
The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis.
Biol Reprod. 2015;94(1):22 - PMID: 26658708
Regulation of epithelial function, differentiation, and remodeling in the epididymis.
Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.
Localization of the gap junction protein, connexin 43, and E-cadherin/Cadherin-1 in the proximal mouse epididymis.
Mol Reprod Dev. 2015;82(10):723 - PMID: 26331361
Renal Intercalated Cells Sense and Mediate Inflammation via the P2Y14 Receptor.
Role of Testicular Luminal Factors on Basal Cell Elongation and Proliferation in the Mouse Epididymis.
CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation via the ZONAB pathway.
High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa.
ROS1 Signaling Regulates Epithelial Differentiation in the Epididymis.
Epithelial Basal Cells Are Distinct from Dendritic Cells and Macrophages in the Mouse Epididymis.
Dedifferentiation of committed epithelial cells into stem cells in vivo.
Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells.
Regulation of Luminal Acidification by the V-ATPase.
Plasticity of basal cells during postnatal development in the rat epididymis.
Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymis.