Breton, Sylvie, PhD
Sylvie Breton is a PhD in Biophysics who specializes in the cell biology of membrane transport. She studies luminal acidification and intercellular communication networks in the kidney and epididymis. She became Professor of Medicine at Harvard Medical School in 2012, and she has been at MGH since 1994.
Selected Publications (from total of 111)
The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer.
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.
The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis.
Regulation of epithelial function, differentiation, and remodeling in the epididymis.
Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.
Localization of the gap junction protein, connexin 43, and E-cadherin/Cadherin-1 in the proximal mouse epididymis.
Mol Reprod Dev. 2015;82(10):723 - PMID: 26331361
Renal Intercalated Cells Sense and Mediate Inflammation via the P2Y14 Receptor.
Role of Testicular Luminal Factors on Basal Cell Elongation and Proliferation in the Mouse Epididymis.
CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation via the ZONAB pathway.
High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa.
ROS1 Signaling Regulates Epithelial Differentiation in the Epididymis.
Epithelial Basal Cells Are Distinct from Dendritic Cells and Macrophages in the Mouse Epididymis.
Dedifferentiation of committed epithelial cells into stem cells in vivo.
Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells.
Regulation of Luminal Acidification by the V-ATPase.