Shaw Lab
The overall goal of our research is to define biologic pathways important for the development and treatment of metabolic and cardiovascular disease in humans. Since these diseases involve a complex interplay between genetic, epigenetic, and environmental factors, we study them using a systems biology approach. Namely, we analyze human cells in their baseline state or following systematic perturbation, using genome-wide gene expression measurements, high-throughput small molecule screens, bioinformatic analysis, and molecular imaging.
By design, many of our high-throughput small molecule screens use small molecules of known effect, including FDA-approved drugs, or novel compounds that modulate proteins targeted by existing drugs. Because of this, our work can lead to novel therapeutic hypotheses that may be rapidly translated to human applications.