About

Herbert Lin's Lab

Herbert_lin

The overall theme of my laboratory is to understand the role of the TGF-β/BMP signaling pathways in health and disease. My laboratory has currently three major areas of interest: 1) Understanding the role of the RGM/DRAGON family of BMP co-receptors in the regulation of BMP signaling; 2) Determining the specific role of hemojuvelin (HJV) in the regulation of hepcidin expression and iron metabolism; 3) Study of TGF-β/BMP ligands interaction with receptors using biochemical and cell biology techniques. Ultimately, by studying this complex but important signaling system, we aim to generate new knowledge that will lead to novel therapeutic options for chronic diseases such as chronic kidney disease, hemochromatosis and anemia of chronic disease.

Recent Publications (more...)

Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ
Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice.
J Clin Invest. 2009;:ePub - PMID: 19809161 - PMCID: PMC2769199
Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B, Lin HY, Pietrangelo A, Babitt JL
Bone morphogenetic protein signaling is impaired in an Hfe knockout mouse model of hemochromatosis.
Gastroenterology. 2009;137(4):1489-97 - PMID: 19591830 - PMCID: PMC2757523
Andriopoulos Jr B, Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, Knutson MD, Pietrangelo A, Vukicevic S, Lin HY, Babitt JL
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.
Nat Genet. 2009;41(4):482-7 - PMID: 19252486

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