About

Weissleder, Ralph, MD, PhD

Ralph_weissleder
Phone: 617-726-8226
Email: rweissleder@mgh.harvard.edu
Lab: Weissleder

Research

Ralph Weissleder serves as the Director of the Center for Systems Biology at MGH. He is a Professor at Harvard Medical School, Director of the Center for Molecular Imaging Research, and Attending Clinician (Interventional Radiology) at MGH. Dr. Weissleder is also a member of the Dana Farber Harvard Cancer Center, an Associate Member of the Broad Institute (Chemical Biology Program) and a member of the Harvard Stem Cell Institute (HSCI). He is a world leader in applying molecular imaging tools to the study of complex human diseases. He has made fundamental discoveries in early disease detection, development of nanomaterials for sensing and systems analysis. His research has been translational and several of his developments have led to advanced clinical trials.

Dr. Weissleder is currently the principal investigator of several RO1 NIH grants, a P50 Center grant, a U24 grant, and a UO1 consortium focusing on nanotechnology. He has published over 500 publications in peer reviewed journals. His work has been honored with numerous awards including the J. Taylor International Prize in Medicine, the Millenium Pharmaceuticals Innovator Award, the AUR Memorial Award, the ARRS President's Award, The Society for Molecular Imaging Lifetime Achievement Award and the Academy of Molecular Imaging 2006 Distinguished Basic Scientist Award.

Publications

Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T
Restoration of p53 function leads to tumour regression in vivo.
Nature. 2007;445:661-5 - PMID: 17251932
Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T
A spatially and temporally restricted mouse model of soft tissue sarcoma.
Nat Med. 2007;13(8):992-997 - PMID: 17676052
Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
J Clin Invest. 2007;117(1):195-205 - PMID: 17200719 - PMCID: PMC1716211
Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg F, Weissleder R, Carson W, Chiocca A, Kaur B.
Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy
J Natl Cancer I. 2007;(99) 23:1768-1781 - PMID: 18042934
Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D.
Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk
J Exp Med. 2007;204:1911-1922 - PMID: 17646407 - PMCID: PMC2118664
Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.
J Exp Med. 2007;204(12):3037-47 - PMID: 18025128 - PMCID: PMC2118517
Jaffer FA, Libby P, Weissleder R
Molecular imaging of cardiovascular disease.
Circulation. 2007;116(9):1052-61 - PMID: 17724271
Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V
Fluorescence Tomography and Magnetic Resonance Imaging of Myocardial Macrophage Infiltration in Infarcted Myocardium In Vivo.
Circulation. 2007;115:1384-1391 - PMID: 17339546
Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R
Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease.
Circulation. 2007;115:377-386 - PMID: 17224478
Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R
Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor.
Circulation. 2007;115(17):2292-8 - PMID: 17420353
Sosnovik DE, Nahrendorf M, Weissleder R
Molecular magnetic resonance imaging in cardiovascular medicine.
Circulation. 2007;115(15):2076-86 - PMID: 17438163
Aikawa E, Nahrendorf M, Figueiredo JL, Swirski F, Shtatland T, Kohler RH, Jaffer F, Aikawa M, Weissleder R.
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.
Circulation. 2007;116(24):2841-50 - PMID: 18040026
Nahrendorf M, Sosnovik D, Waterman P, Swirski F, Pande A, Aikawa E, Figueiredo JL, Pittet M, Weissleder R.
Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct
Circ Res. 2007;100:1218-1225 - PMID: 17379832
Pittet M, Grimm J, Berger C, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski F, Weissleder R.
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
P Natl Acad Sci U S A. 2007;104:12457-12461 - PMID: 17640914 - PMCID: PMC1941490
Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K
Mast cells are an essential hematopoietic component for polyp development.
P Natl Acad Sci U S A. 2007;104:19977-82 - PMID: 18077429 - PMCID: PMC2148408
Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K
MicroRNA-21 Knockdown Disrupts Glioma Growth In vivo and Displays Synergistic Cytotoxicity with Neural Precursor Cell Delivered S-TRAIL in Human Gliomas.
Cancer Res. 2007;67(19):8994-9000 - PMID: 17908999
Arwert E, Hingtgen S, Figueiredo JL, Bergquist H, Mahmood U, Weissleder R, Shah K.
Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo
Cancer Res. 2007;67 (15):7335-7342 - PMID: 17671203
Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Rachamimov AS, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.
Cancer Res. 2007;67(19):9398-406 - PMID: 17909049
Izmailova ES, Paz N, Alencar H, Chun M, Schopf L, Hepperle M, Lane JH, Harriman G, Xu Y, Ocain T, Weissleder R, Mahmood U, Healy AM, Jaffee B
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
Arth Rheum/AR C Res. 2007;56(1):117-128 - PMID: 17195214
Sosnovik DE, Weissleder R
Emerging concepts in molecular MRI.
Curr Opin Biotech. 2007;18(1):4-10 - PMID: 17126545
Kozloff KM, Weissleder R, Mahmood U
Non-Invasive Optical Detection of Bone Mineral.
J Bone Miner Res. 2007;(22) 8:1208-1216 - PMID: 17488196
Shepherd J, Hilderbrand SA, Waterman P, Heinecke JW, Weissleder R, Libby P
A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages.
Chem Biol. 2007;14:1221-31 - PMID: 18022561
Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L
Covalent Reactions of Wortmannin under Physiological Conditions.
Chem Biol. 2007;14(3):321-8 - PMID: 17379147
Harisinghani M, Ross R, Guimaraes A, Weissleder R
Utility of a New Bolus-Injectable Nanoparticle for Clinical Cancer Staging
Neoplasia. 2007;(9)12:1160-1165 - PMID: 18084623 - PMCID: PMC2134912
Kock N, Kasmieh R, Weissleder R, Shah K
Tumor Therapy Mediated by Lentiviral Expression of shBcl-2 and S-TRAIL.
Neoplasia. 2007;9(5):435-42 - PMID: 17534449 - PMCID: PMC1877976
Upadhyay R, Sheth RA, Weissleder R, Mahmood U
Quantitative Real-time Catheter-based Fluorescence Molecular Imaging in Mice.
Radiology. 2007;245(2):523-31 - PMID: 17940307
Montet X, Figueiredo JL, Alencar H, Ntziachristos V, Mahmood U, Weissleder R.
Tomographic fluorescence imaging of tumor vascular volume in mice.
Radiology. 2007;242 (3):751-758 - PMID: 17325064
Alencar H, Funovics MA, Figueiredo J, Sawaya H, Weissleder R, Mahmood U
Colonic Adenocarcinomas: Near-Infrared Microcatheter Imaging of Smart Probes for Early Detection.
Radiology. 2007;244(1):232-8 - PMID: 17507718
Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L
Multiparameter Magnetic Relaxation Switch Assays.
Anal Chem. 2007;(79) 23:8863-9 - PMID: 17983206
Kim YM, Hilderbrand S, Weissleder R, Tung CH
Sugar sensing based on induced pH changes
Chem Commun. 2007;(22):2299-2301 - PMID: 17534523
Hilderbrand S, Weissleder R.
Optimized pH-responsive cyanine fluorochromes for detection of acidic environments
Chem Commun. 2007;(26):2747-9 - PMID: 17594041
Bouffard J, Kim Y, Swager TM, Weissleder R, Hilderbrand SA
A Highly Selective Fluorescent Probe for Thiol Bioimaging.
Org Lett. 2007;10 :37-40 - PMID: 18062694
Gee MS, Upadhyay R, Bergquist H, Weissleder R, Josephson L, Mahmood U
Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment.
Int J Cancer. 2007;(121) 11:2492-2500 - PMID: 17683072
Law B, Weissleder R, Tung CH
Protease-Sensitive Fluorescent Nanofibers.
Bioconjugate Chem. 2007;(18) 6 ::1701-1704 - PMID: 17915958 - PMCID: PMC2528070
Nahrendorf M, Badea C, Hedlund LW, Figueiredo JL, Sosnovik DE, Johnson GA, Weissleder R
High Resolution Imaging of Murine Myocardial Infarction With Delayed Enhancement Cine Micro-CT.
Am J Physiol-Heart C. 2007;292(6):3172-8 - PMID: 17322414 - PMCID: PMC2680216
Shtatland T, Guettler D, Kossodo M, Pivovarov M, Weissleder R
PepBank - a database of peptides based on sequence text mining and public peptide data sources.
BMC Bioinformatics. 2007;8(1):280 - PMID: 17678535 - PMCID: PMC1976427
Ho NH, Weissleder R, Tung CH
A Self-Immolative Reporter For beta-Galactosidase Sensing.
Chembiochem. 2007;8:560-566 - PMID: 17300128
Montet-Abou K, Montet X, Weissleder R, Josephson L
Cell internalization of magnetic nanoparticles using transfection agents.
Mol Imaging. 2007;(6) 1:1-9 - PMID: 17311760
Tam JM, Upadhyay R, Pittet MJ, Weissleder R, Mahmood U
Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging.
Mol Imaging. 2007;6(4):269-76 - PMID: 17711782
Sheth RA, Upadhyay R, Weissleder R, Mahmood U
Real-time multichannel imaging framework for endoscopy, catheters, and fixed geometry intraoperative systems.
Mol Imaging. 2007;6(3):147-55 - PMID: 17532881
Farrar CT, Dai G, Novikov M, Rosenzweig A, Weissleder R, Rosen BR, Sosnovik DE
Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging.
NMR Biomed. 2007;:ePub - PMID: 17918777 - PMCID: PMC2629945
Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R
A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses.
PLoS ONE. 2007;2(10):e1075 - PMID: 17957257 - PMCID: PMC2034600
Kelly KA, Carson J, McCarthy JR, Weissleder R
Novel Peptide Sequence ("IQ-tag") with High Affinity for NIR Fluorochromes Allows Protein and Cell Specific Labeling for In Vivo Imaging.
PLoS ONE. 2007;2:e665 - PMID: 17653285 - PMCID: PMC1919420
McCarthy JR, Weissleder R
Model Systems for Fluorescence and Singlet Oxygen Quenching by Metalloporphyrins.
ChemMedChem. 2007;2:360-365 - PMID: 17245681
McCarthy J, Kelly KA, Sun EY, Weissleder R.
Targeted delivery of multifunctional magnetic nanoparticles
NanoMedicine. 2007;2(2):153-167 - PMID: 17716118
Kim Y, Choi Y, Weissleder R, Tung CH
Membrane permeable esterase-activated fluorescent imaging probe.
Bioorg Med Chem Lett. 2007;17(18):5054-7 - PMID: 17664067 - PMCID: PMC1995663
Grimm J, Kircher MF, Weissleder R
Cell tracking : Principles and applications.
Radiologe. 2007;47(1):25-33 - PMID: 17187264
Nahrendorf M, Weissleder R
Advances in cardiovascular medicine through molecular imaging.
Radiologe. 2007;47(1):18-24 - PMID: 17187263
Hilderbrand SA, Weissleder R
One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes.
Tetrahedron Lett. 2007;48(25):4383-4385 - PMID: 19834587 - PMCID: PMC2761723

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