About

Weissleder, Ralph, MD, PhD

Ralph_weissleder
Phone: 617-726-8226
Email: rweissleder@mgh.harvard.edu
Lab: Weissleder

Research

Ralph Weissleder serves as the Director of the Center for Systems Biology at MGH. He is a Professor at Harvard Medical School, Director of the Center for Molecular Imaging Research, and Attending Clinician (Interventional Radiology) at MGH. Dr. Weissleder is also a member of the Dana Farber Harvard Cancer Center, an Associate Member of the Broad Institute (Chemical Biology Program) and a member of the Harvard Stem Cell Institute (HSCI). He is a world leader in applying molecular imaging tools to the study of complex human diseases. He has made fundamental discoveries in early disease detection, development of nanomaterials for sensing and systems analysis. His research has been translational and several of his developments have led to advanced clinical trials.

Dr. Weissleder is currently the principal investigator of several RO1 NIH grants, a P50 Center grant, a U24 grant, and a UO1 consortium focusing on nanotechnology. He has published over 500 publications in peer reviewed journals. His work has been honored with numerous awards including the J. Taylor International Prize in Medicine, the Millenium Pharmaceuticals Innovator Award, the AUR Memorial Award, the ARRS President's Award, The Society for Molecular Imaging Lifetime Achievement Award and the Academy of Molecular Imaging 2006 Distinguished Basic Scientist Award.

Publications

Jaffer F, Weissleder R
Molecular Imaging in the Clinical Arena
JAMA-J Am Med Assoc. 2005;293(7):855-62 - PMID: 15713776
Ntziachristos V, Ripoll J, Wang L, Weissleder R
Looking and Listening to light: the evolution of whole-body photonic imaging
Nat Biotechnol. 2005;23:313-320 - PMID: 15765087
Weissleder R, Kelly K, Sun E, Shtatland T, Josephson L.
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
Nat Biotechnol. 2005;23:1418-1423 - PMID: 16244656
Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R, Mathis D.
Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes
J Clin Invest. 2005;115(9):2454-2461 - PMID: 16110329 - PMCID: PMC1187933
Chen J, Tung CH, Allport JR, Chen S, Weissleder R, Huang PL.
Near-Infrared Fluorescent Imaging of Matrix Metalloproteinase Activity After Myocardial Infarction
Circulation. 2005;111:1800-1805 - PMID: 15809374
Kelly KA, Allport JR, Tsourkas A, Shinde-Patil VR, Josephson L, Weissleder R.
Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle
Circ Res. 2005;96(3):327-36 - PMID: 15653572
McCarthy JR, Perez JM, Brueckner C, Weissleder R
Polymeric Nanoparticle Preparation that Eradicates Tumors.
Nano Lett. 2005;5:2552-6 - PMID: 16351214
Zacharakis G, Kambara H, Shih H, Ripoll J, Grimm J, Saeki Y, Weissleder R, Ntziachristos V.
Volumetric tomography of fluorescent proteins through small animals in vivo
P Natl Acad Sci U S A. 2005;102:18252-18257 - PMID: 16344470 - PMCID: PMC1317905
Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K.
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-{beta} signals in vivo
P Natl Acad Sci U S A. 2005;102(2):419-24 - PMID: 15623559 - PMCID: PMC544311
Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, Jacks T, Weissleder R.
Use of gene expression profiling to direct in vivo molecular imaging of lung cancer
P Natl Acad Sci U S A. 2005;102(40):14404-14409 - PMID: 16183744 - PMCID: PMC1242291
Shah K, Bureau E, Kim DE, Yang K, Tang Y, Weissleder R, Breakefield XO.
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression
Ann Neurol. 2005;57(1):34-41 - PMID: 15622535
Montet X, Ntziachristos V, Grimm J, Weissleder R.
Tomographic Fluorescence Mapping of Tumor Targets
Cancer Res. 2005;65 (14):6330-6336 - PMID: 16024635
Kim YR, Yudina A, Figueiredo J, Reichardt W, Hu-Lowe D, Petrovsky A, Kang HW, Torres D, Mahmood U, Weissleder R, Bogdanov AA Jr.
Detection of Early Antiangiogenic Effects in Human Colon Adenocarcinoma Xenografts: In vivo Changes of Tumor Blood Volume in Response to Experimental VEGFR Tyrosine Kinase Inhibitor
Cancer Res. 2005;65(20):9253-60 - PMID: 16230386
Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R.
In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging
Cancer Res. 2005;65(18):8324-30 - PMID: 16166309
Kelloff GJ, Krohn KA, Larson SM, Weissleder R, Mankoff DA, Hoffman JM, Link JM, Guyton KZ, Eckelman WC, Scher HI, O
The progress and promise of molecular imaging probes in oncologic drug development.
Clin Cancer Res. 2005;11(22):7967-85 - PMID: 16299226
Shah K, Tung CH, Breakefield X, Weissleder R.
In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis
Mol Ther. 2005;11 (6):926-931 - PMID: 15922963
Tannous BA, Kim DE, Fernandez JL, Weissleder R, Breakefield XO.
Codon-optimized gaussia luciferase cDNA for Mammalian gene expression in culture and in vivo
Mol Ther. 2005;11(3):435-43 - PMID: 15727940
Reichardt W, Hu-Lowe D, Torres D, Weissleder R, Bogdanov A Jr.
Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma model
Neoplasia. 2005;7(9):847-53 - PMID: 16229807 - PMCID: PMC1351316
Funovics M, Montet X, Reynolds F, Weissleder R, Josephson L.
Nanoparticles for the Optical Imaging of Tumor E-selectin
Neoplasia. 2005;7(10):904-11 - PMID: 16242073
Alencar H, Mahmood U, Kawano Y, Hirata T, Weissleder R
Novel Multiwavelength Microscopic Scanner for Mouse Imaging.
Neoplasia. 2005;7(11):977-983 - PMID: 16331883 - PMCID: PMC1502018
Shinde Patil VR, Friedrich EB, Wolley AE, Gerszten RE, Allport JR, Weissleder R.
Bone Marrow-Derived lin(-)c-kit(+)Sca-1(+) Stem Cells Do Not Contribute to Vasculogenesis in Lewis Lung Carcinoma
Neoplasia. 2005;7(3):234-40 - PMID: 15799823 - PMCID: PMC1501134
Tsourkas A, Newton G, Perez JM, Basilion J, Weissleder R.
Detection of Peroxidase-Mediated Dityrosine Formation with Enhanced Yellow Fluorescent Protein
Anal Chem. 2005;77:2862-2867 - PMID: 15859603
Kim DE, Jaffer FA, Weissleder R, Tung CH, Schellingerhout D.
Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis
J Cerebr Blood F Met. 2005;25(2):226-33 - PMID: 15678125
Querol M, Chen JW, Weissleder R, Bogdanov A Jr.
DTPA-bisamide-Based MR Sensor Agents for Peroxidase Imaging
Org Lett. 2005;7(9):1719-22 - PMID: 15844889
Alencar H, King R, Funovics M, Stout C, Weissleder R, Mahmood U.
A novel mouse model for segmental orthotopic colon cancer
Int J Cancer. 2005;117(3):335-9 - PMID: 15900588
Figueiredo JL, Alencar H, Weissleder R, Mahmood U
Near infrared thoracoscopy of tumoral protease activity for improved detection of peripheral lung cancer.
Int J Cancer. 2005;118(11):2672-7 - PMID: 16380983
Hilderbrand SA, Kelly KA, Weissleder R, Tung CH.
Monofunctional near-infrared fluorochromes for imaging applications
Bioconjugate Chem. 2005;16(5):1275-81 - PMID: 16173808
Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L.
Synthesis and Activity of C11-Modified Wortmannin Probes for P13 Kinase
Bioconjugate Chem. 2005;(3):669-675 - PMID: 15898736
Reynolds F, Weissleder R, Josephson L.
Protamine as an efficient membrane-translocating Peptide
Bioconjugate Chem. 2005;16(5):1240-5 - PMID: 16173804
Tsourkas A, Shinde-Patil VR, Kelly KA, Patel P, Wolley A, Allport JR, Weissleder R.
In Vivo Imaging of Activated Endothelium Using an Anti-VCAM-1 Magneto optical Probe
Bioconjugate Chem. 2005;(3):576-581 - PMID: 15898724
Brown AB, Mahmood U, Cortes ML, Tang Y, Dai G, Stemmer-Rachamimov A, Prabhakar S, Leishear K, Onda H, Kwiatkowski D, Weissleder R, Breakefield X
Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery.
Hum Gene Ther. 2005;16:1367-76 - PMID: 16390268
Shih HA, Harisinghani M, Zietman AL, Wolfgang JA, Saksena M, Weissleder R.
Mapping of nodal disease in locally advanced prostate cancer: Rethinking the clinical target volume for pelvic nodal irradiation based on vascular rather than bony anatomy
Int J Radiat Oncol Biol Phys. 2005;63(4):1262-9 - PMID: 16253781
Bremer C, Ntziachristos V, Weitkamp B, Theilmeier G, Heindel W, Weissleder R.
Optical Imaging of Spontaneous Breast Tumors Using Protease Sensing
Invest Radiol. 2005;(6):321-327 - PMID: 15905717
Choi HK, Yessayan D, Choi HJ, Schellenberger E, Bogdanov A, Josephson L, Weissleder R, Ntziachristos V.
Quantitative analysis of chemotherapeutic effects in tumors using in vivo staining and correlative histology
Cell Oncol. 2005;27(3):183-90 - PMID: 16037639
Chen WT, Mahmood U, Weissleder R, Tung CH
Arthritis imaging using a near-infrared fluorescence folate-targeted probe
Arthritis Res Ther. 2005;7:R310-R317 - PMID: 15743478 - PMCID: PMC1065321
Shah K, Weissleder R
Molecular Optical Imaging: Applications Leading to the Development of Present Day Therapeutics
NeuroRx. 2005;2:215-225 - PMID: 15897946 - PMCID: PMC1064987
Tung CH, Quinti L, Jaffer F, Weissleder R
A Branched Fluorescent Peptide Probe for Imaging of Activated Platelets
Mol Pharmacol. 2005;2:92-95 - PMID: 15804182
Koch AM, Reynolds F, Merkle HP, Weissleder R, Josephson L.
Transport Of Surface-Modified Nanoparticles Through Cell Monolayers
Chembiochem. 2005;6(2):337-345 - PMID: 15651046
Law B, Weissleder R, Tung CH.
Mechanism-Based Fluorescent Reporter for Protein Kinase A Detection
Chembiochem. 2005;6(8):1361-1367 - PMID: 16010698
Chen WT, Khazaie K, Zhang G, Weissleder R, Tung CH
Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe
Mol Imaging. 2005;4 (1):67-74 - PMID: 15912902
Pivovarov M, Bhandary G, Mahmood U, Zahlmann G, Naraghi M, Weissleder R
MIPortal: A High Capacity Server for Molecular Imaging Research.
Mol Imaging. 2005;4(4):425-31 - PMID: 16285904
Gillies R, Hoffman J, Lam K, Menkens A, Piwnica-Worms D, Sullivan D, Weissleder R.
Meeting Report: High-Throughput Technologies for In Vivo Imaging Agents
Mol Imaging. 2005;4:1-6
Montet-Abou K, Montet X, Weissleder R, Josephson L.
Transfection agent induced nanoparticle cell loading
Mol Imaging. 2005;4(3):165-71 - PMID: 16194448
Wunder A, Schellenberger E, Mahmood U, Bogdanov A Jr, Muller-Ladner U, Weissleder R, Josephson L.
Methotrexate-induced accumulation of fluorescent annexin v in collagen-induced arthritis
Mol Imaging. 2005;4(1):1-6 - PMID: 15967121
Zacharakis G, Ripoll J, Weissleder R, Ntziachristos V.
Fluorescent protein tomography scanner for small animal imaging
IEEE T Med Imaging. 2005;24(7):878-85 - PMID: 16011317
Galande A, Weissleder R, Tung CH.
An Effective Method of On-Resin Disulfide Bond Formation in Peptides
J Comb Chem. 2005;7:174-177 - PMID: 15762743
Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L.
Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle
Magn Reson Med. 2005;54(3):718-724 - PMID: 16086367
Graves EE, Yessayan D, Turner G, Weissleder R, Ntziachristos V.
Validation of in vivo fluorochrome concentrations measured using fluorescence molecular tomography
J Biomed Opt. 2005;10(4):44019 - PMID: 16178652
Law B, Hsiao JK, Bugge TH, Weissleder R, Tung CH.
Optical zymography for specific detection of urokinase plasminogen activator activity in biological samples
Anal Biochem. 2005;338(1):151-158 - PMID: 15707946
Querol Sans M*, Chen JW*, Weissleder R, Bogdanov AA
Myeloperoxidase Activity Imaging Using (67)Ga Labeled Substrate.
Mol Imaging Biol. 2005;:1-8 - PMID: 16292477
Reynolds F, O'loughlin T, Weissleder R, Josephson L.
Method of Determining Nanoparticle Core Weight
Anal Bioanal Chem. 2005;77(3):814-817 - PMID: 15679348
Zhu B, Jaffer F, Nztiachristos V, Weissleder R
Development of a near infrared fluorescence catheter: operating characteristics and feasibility for atherosclerotic plaque detection
J Phys D Appl Phys. 2005;38:2701-2707
Harisinghani MG, Saksena M, Ross RW, Tabatabaei S, Dahl D, McDougal S, Weissleder R
A pilot study of lymphotrophic nanoparticle-enhanced magnetic resonance imaging technique in early stage testicular cancer: a new method for noninvasive lymph node evaluation.
Urology. 2005;66(5):1066-71 - PMID: 16286125
Kim CF, Jackson EL, Kirsch DG, Grimm J, Shaw AT, Lane K, Kissil J, Olive KP, Sweet-Cordero A, Weissleder R, Jacks T
Mouse Models of Human Non-Small-Cell Lung Cancer: Raising the Bar.
Cold Spring Harb Symp Quant Biol. 2005;70:241-250 - PMID: 16869760
Sosnovik D, Weissleder R
Magnetic resonance and fluorescence based molecular imaging technologies.
Prog Drug Res. 2005;62:83-115 - PMID: 16329255
Bogdanov AA Jr, Chen JW, Kang HW, Weissleder R.
Magnetic resonance signal amplification probes
Ernst Schering Res Found Workshop. 2005;49:147-57 - PMID: 15524215

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