About

Weissleder, Ralph, MD, PhD

Ralph_weissleder
Phone: 617-726-8226
Email: rweissleder@mgh.harvard.edu
Lab: Weissleder

Research

Ralph Weissleder serves as the Director of the Center for Systems Biology at MGH. He is a Professor at Harvard Medical School, Director of the Center for Molecular Imaging Research, and Attending Clinician (Interventional Radiology) at MGH. Dr. Weissleder is also a member of the Dana Farber Harvard Cancer Center, an Associate Member of the Broad Institute (Chemical Biology Program) and a member of the Harvard Stem Cell Institute (HSCI). He is a world leader in applying molecular imaging tools to the study of complex human diseases. He has made fundamental discoveries in early disease detection, development of nanomaterials for sensing and systems analysis. His research has been translational and several of his developments have led to advanced clinical trials.

Dr. Weissleder is currently the principal investigator of several RO1 NIH grants, a P50 Center grant, a U24 grant, and a UO1 consortium focusing on nanotechnology. He has published over 500 publications in peer reviewed journals. His work has been honored with numerous awards including the J. Taylor International Prize in Medicine, the Millenium Pharmaceuticals Innovator Award, the AUR Memorial Award, the ARRS President's Award, The Society for Molecular Imaging Lifetime Achievement Award and the Academy of Molecular Imaging 2006 Distinguished Basic Scientist Award.

Publications

Jaffer FA, Tung CH, Wykrzykowska JJ, Ho NH, Houng AK, Reed GL, Weissleder R
Molecular Imaging of Factor XIIIa Activity in Thrombosis Using a Novel, Near-Infrared Fluorescent Contrast Agent That Covalently Links to Thrombi.
Circulation. 2004;110(2):170-6 - PMID: 15210587
Harisinghani MG, Weissleder R
Sensitive, noninvasive detection of lymph node metastases.
PLoS Med. 2004;1(3):e66 - PMID: 15630471 - PMCID: PMC539052
Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L
Magnetic Relaxation Switch Immunosensors Detect Enantiomeric Impurities
Angew Chem Int Edit. 2004;43(18):2395-2399 - PMID: 15114571
Jaffer FA, Weissleder R
Seeing within: molecular imaging of the cardiovascular system
Circ Res. 2004;94(4):433-45 - PMID: 15001542
Perez JM, Simeone FJ, Tsourkas A, Josephson L, Weissleder R
Peroxidase substrate nanosensors for MR imaging
Nano Lett. 2004;4:119-122
Denis MC, Mahmood U, Benoist C, Mathis D, Weissleder R
Imaging inflammation of the pancreatic islets in type 1 diabetes.
P Natl Acad Sci U S A. 2004;101(34):12634-9 - PMID: 15304647 - PMCID: PMC515109
Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A Jr, Josephson L, Weissleder R
Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate.
P Natl Acad Sci U S A. 2004;101(33):12294-9 - PMID: 15304657 - PMCID: PMC514472
Shah K, Tung CH, Chang CH, Slootweg E, O'Loughlin T, Breakefield XO, Weissleder R
In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas
Cancer Res. 2004;64:273-8 - PMID: 14729634
Shah K, Tung CH, Yang K, Weissleder R, Breakefield XO
Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy
Cancer Res. 2004;64(9):3236-42 - PMID: 15126365
Kelly K, Alencar H, Funovics M, Mahmood U, Weissleder R
Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide.
Cancer Res. 2004;64(17):6247-51 - PMID: 15342411
Grimm J, Perez JM, Josephson L, Weissleder R
Novel nanosensors for rapid analysis of telomerase activity
Cancer Res. 2004;64:639-43 - PMID: 14744779
Gondi CS, Lakka SS, Yanamandra N, Olivero WC, Dinh DH, Gujrati M, Tung CH, Weissleder R, Rao JS
Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas.
Cancer Res. 2004;64(12):4069-77 - PMID: 15205313
Tung CH, Zeng Q, Shah K, Kim DE, Schellingerhout D, Weissleder R
In Vivo Imaging of ?-Galactosidase Activity Using Far Red Fluorescent Switch
Cancer Res. 2004;64:1579-1583 - PMID: 14996712
Wunder A, Tung CH, Muller-Ladner U, Weissleder R, Mahmood U
In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response.
Arth Rheum/AR C Res. 2004;50(8):2459-65 - PMID: 15334458
Zhao M, Weissleder R
Intracellular cargo delivery using tat peptide and derivatives
Med Res Rev. 2004;24:1-12 - PMID: 14595670
Kim DE, Schellingerhout D, Ishii K, Shah K, Weissleder R
Imaging of Stem Cell Recruitment to Ischemic Infarcts in a Murine Model
Stroke. 2004;35:952-7 - PMID: 14988578
Law B, Curino A, Bugge TH, Weissleder R, Tung CH
Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter.
Chem Biol. 2004;11(1):99-106 - PMID: 15112999
Messerli SM, Prabhakar S, Tang Y, Shah K, Cortes ML, Murthy V, Weissleder R, Breakefield XO, Tung CH
A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe.
Neoplasia. 2004;6(2):95-105 - PMID: 15140398 - PMCID: PMC1502090
Funovics MA, Weissleder R, Mahmood U
Catheter-based in vivo imaging of enzyme activity and gene expression: feasibility study in mice.
Radiology. 2004;231(3):659-66 - PMID: 15163807
Shah K, Jacobs A, Breakefield XO, Weissleder R
Molecular imaging of gene therapy for cancer
Gene Ther. 2004;11(15):1175-87 - PMID: 15141158
Graves EE, Weissleder R, Ntziachristos V
Fluorescence molecular imaging of small animal tumor models.
Curr Mol Med. 2004;4(4):419-30 - PMID: 15354872
Pham W, Choi Y, Weissleder R, Tung CH
Developing a Peptide-Based Near-Infrared Molecular Probe for Protease Sensing.
Bioconjugate Chem. 2004;15(6):1403-1407 - PMID: 15546208
Banerjee P, Reichardt W, Weissleder R, Bogdanov A Jr
Novel hyperbranched dendron for gene transfer in vitro and in vivo.
Bioconjugate Chem. 2004;15(5):960-8 - PMID: 15366948
Schellenberger EA, Sosnovik D, Weissleder R, Josephson L
Magneto/Optical annexin v, a multimodal protein.
Bioconjugate Chem. 2004;15(5):1062-7 - PMID: 15366960
Metelev V, Weissleder R, Bogdanov A Jr
Synthesis and Properties of Fluorescent NF-kappaB-Recognizing Hairpin Oligodeoxyribonucleotide Decoys.
Bioconjugate Chem. 2004;15(6):1481-1487 - PMID: 15546218
Kircher MF, Weissleder R, Josephson L
A dual fluorochrome probe for imaging proteases
Bioconjugate Chem. 2004;15:242-8 - PMID: 15025519
Perez JM, Josephson L, Weissleder R
Use of magnetic nanoparticles as nanosensors to probe for molecular interactions
Chembiochem. 2004;5:261-4 - PMID: 14997516
Schellenberger EA, Reynolds F, Weissleder R, Josephson L
Surface-functionalized nanoparticle library yields probes for apoptotic cells
Chembiochem. 2004;5:275-9 - PMID: 14997519
Schellenberger EA, Weissleder R, Josephson L
Optimal modification of annexin v with fluorescent dyes
Chembiochem. 2004;5:271-4 - PMID: 14997518
Pham W, Kircher MF, Weissleder R, Tung CH
Enhancing membrane permeability by Fatty acylation of oligoarginine peptides.
Chembiochem. 2004;5(8):1148-51 - PMID: 15300843
Chen WT, Tung CH, Weissleder R
Imaging reactive oxygen species in arthritis.
Mol Imaging. 2004;3(3):159-62 - PMID: 15530251
Kim YR, Savellano MD, Savellano DH, Weissleder R, Bogdanov A Jr
Measurement of tumor interstitial volume fraction: Method and implication for drug delivery
Magn Reson Med. 2004;52(3):485-94 - PMID: 15334566
Chen JW, Pham W, Weissleder R, Bogdanov A Jr
Human myeloperoxidase: A potential target for molecular MR imaging in atherosclerosis.
Magn Reson Med. 2004;52(5):1021-8 - PMID: 15508166
Kelly KA, Reynolds F, Weissleder R, Josephson L
Fluorescein isothiocyanate-hapten immunoassay for determination of peptide-cell interactions.
Anal Biochem. 2004;330(2):181-5 - PMID: 15203322
Allport JR, Shinde Patil VR, Weissleder R
Murine Neuronal Progenitor Cells are Preferentially Recruited to Tumor Vasculature via alpha(4)-integrin and SDF-1alpha-Dependent Mechanisms.
Cancer Biol Ther. 2004;3(9):838-44 - PMID: 15254391
Graves EE, Culver JP, Ripoll J, Weissleder R, Ntziachristos V
Singular-value analysis and optimization of experimental parameters in fluorescence molecular tomography
J Opt Soc Am A . 2004;21(2):231-41 - PMID: 14763766
Tsourkas A, Weissleder R
Illuminating the dynamics of intracellular activity with
Mech Chem Biosyst. 2004;1:133-45 - PMID: 16783939

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