About

Weissleder, Ralph, MD, PhD

Ralph_weissleder
Phone: 617-726-8226
Email: rweissleder@mgh.harvard.edu
Lab: Weissleder

Research

Ralph Weissleder serves as the Director of the Center for Systems Biology at MGH. He is a Professor at Harvard Medical School, Director of the Center for Molecular Imaging Research, and Attending Clinician (Interventional Radiology) at MGH. Dr. Weissleder is also a member of the Dana Farber Harvard Cancer Center, an Associate Member of the Broad Institute (Chemical Biology Program) and a member of the Harvard Stem Cell Institute (HSCI). He is a world leader in applying molecular imaging tools to the study of complex human diseases. He has made fundamental discoveries in early disease detection, development of nanomaterials for sensing and systems analysis. His research has been translational and several of his developments have led to advanced clinical trials.

Dr. Weissleder is currently the principal investigator of several RO1 NIH grants, a P50 Center grant, a U24 grant, and a UO1 consortium focusing on nanotechnology. He has published over 500 publications in peer reviewed journals. His work has been honored with numerous awards including the J. Taylor International Prize in Medicine, the Millenium Pharmaceuticals Innovator Award, the AUR Memorial Award, the ARRS President's Award, The Society for Molecular Imaging Lifetime Achievement Award and the Academy of Molecular Imaging 2006 Distinguished Basic Scientist Award.

Publications

Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca EA, Basilion JP
In vivo magnetic resonance imaging of transgene expression
Nat Med. 2000;6:351-5 - PMID: 10700241
Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R
Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
Nat Biotechnol. 2000;18:410-4 - PMID: 10748521
Tung CH, Mahmood U, Bredow S, Weissleder R
In vivo imaging of proteolytic enzyme activity using a novel molecular reporter
Cancer Res. 2000;60:4953-8 - PMID: 10987312
Simonova M, Wall A, Weissleder R, Bogdanov A Jr
Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells
Cancer Res. 2000;60:6656-62 - PMID: 11118049
Moore A, Marecos E, Bogdanov A Jr, Weissleder R
Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model
Radiology. 2000;214:568-74 - PMID: 10671613
Schellingerhout D, Rainov NG, Breakefield XO, Weissleder R
Quantitation of HSV mass distribution in a rodent brain tumor model
Gene Ther. 2000;7:1648-55 - PMID: 11083473
Bredow S, Lewin M, Hofmann B, Marecos E, Weissleder R
Imaging of tumour neovasculature by targeting the TGF-beta binding receptor endoglin
Eur J Cancer. 2000;36:675-81 - PMID: 10738134
Hogemann D, Josephson L, Weissleder R, Basilion JP
Improvement of MRI probes to allow efficient detection of gene expression
Bioconjugate Chem. 2000;11:941-6 - PMID: 11087345
Bhorade R, Weissleder R, Nakakoshi T, Moore A, Tung CH
Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptide
Bioconjugate Chem. 2000;11:301-5 - PMID: 10821645
Bogdanov AA Jr, Simonova M, Weissleder R
Engineering membrane proteins for nuclear medicine: applications for gene therapy and cell tracking
Q J Nucl Med Mol IM. 2000;44:224-35 - PMID: 11105587
Wunderbaldinger P, Bogdanov A, Weissleder R
New approaches for imaging in gene therapy
Eur J Radiol. 2000;34:156-65 - PMID: 10927158

Investigator

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