About

Weissleder, Ralph, MD, PhD

Ralph_weissleder
Phone: 617-726-8226
Email: rweissleder@mgh.harvard.edu
Lab: Weissleder

Research

Ralph Weissleder serves as the Director of the Center for Systems Biology at MGH. He is a Professor at Harvard Medical School, Director of the Center for Molecular Imaging Research, and Attending Clinician (Interventional Radiology) at MGH. Dr. Weissleder is also a member of the Dana Farber Harvard Cancer Center, an Associate Member of the Broad Institute (Chemical Biology Program) and a member of the Harvard Stem Cell Institute (HSCI). He is a world leader in applying molecular imaging tools to the study of complex human diseases. He has made fundamental discoveries in early disease detection, development of nanomaterials for sensing and systems analysis. His research has been translational and several of his developments have led to advanced clinical trials.

Dr. Weissleder is currently the principal investigator of several RO1 NIH grants, a P50 Center grant, a U24 grant, and a UO1 consortium focusing on nanotechnology. He has published over 500 publications in peer reviewed journals. His work has been honored with numerous awards including the J. Taylor International Prize in Medicine, the Millenium Pharmaceuticals Innovator Award, the AUR Memorial Award, the ARRS President's Award, The Society for Molecular Imaging Lifetime Achievement Award and the Academy of Molecular Imaging 2006 Distinguished Basic Scientist Award.

Publications

Weissleder R, Tung CH, Mahmood U, Bogdanov A Jr
In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
Nat Biotechnol. 1999;17:375-8 - PMID: 10207887
Bogdanov AA, Lewin M, Weissleder R
Approaches and agents for imaging the vascular system
Adv Drug Deliv Rev. 1999;37:279-293 - PMID: 10837740
Zaharchuk G, Mandeville JB, Bogdanov AA Jr, Weissleder R, Rosen BR, Marota JJ
Cerebrovascular dynamics of autoregulation and hypoperfusion. An MRI study of CBF and changes in total and microvascular cerebral blood volume during hemorrhagic hypotension
Stroke. 1999;30:2197-204; discussion 2204-5 - PMID: 10512929
Bogdanov A Jr, Marecos E, Cheng HC, Chandrasekaran L, Krutzsch HC, Roberts DD, Weissleder R
Treatment of experimental brain tumors with trombospondin-1 derived peptides: an in vivo imaging study
Neoplasia. 1999;1:438-45 - PMID: 10933059 - PMCID: PMC1508110
Mahmood U, Tung CH, Bogdanov A Jr, Weissleder R
Near-infrared optical imaging of protease activity for tumor detection
Radiology. 1999;213:866-70 - PMID: 10580968
Weissleder R
Molecular imaging: exploring the next frontier
Radiology. 1999;212:609-14 - PMID: 10478223
Lewin M, Bredow S, Sergeyev N, Marecos E, Bogdanov A Jr, Weissleder R
In vivo assessment of vascular endothelial growth factor-induced angiogenesis
Int J Cancer. 1999;83:798-802 - PMID: 10597197
Tung CH, Bredow S, Mahmood U, Weissleder R
Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging
Bioconjugate Chem. 1999;10:892-6 - PMID: 10502358
Josephson L, Tung CH, Moore A, Weissleder R
High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates
Bioconjugate Chem. 1999;10:186-91 - PMID: 10077466
Simonova M, Weissleder R, Sergeyev N, Vilissova N, Bogdanov A Jr
Targeting of green fluorescent protein expression to the cell surface
Biochem Bioph Res Co. 1999;262:638-42 - PMID: 10471377
Harisinghani MG, Saini S, Weissleder R, Hahn PF, Yantiss RK, Tempany C, Wood BJ, Mueller PR
MR lymphangiography using ultrasmall superparamagnetic iron oxide in patients with primary abdominal and pelvic malignancies: radiographic-pathologic correlation
Am J Roentgenol. 1999;172:1347-51 - PMID: 10227514
Schima W, Saini S, Petersein J, Weissleder R, Harisinghani M, Mayo-Smith W, Hahn PF
MR imaging of the liver with Gd-BOPTA: quantitative analysis of T1-weighted images at two different doses
J Magn Reson Imaging. 1999;10:80-3 - PMID: 10398981
Enochs WS, Harsh G, Hochberg F, Weissleder R
Improved delineation of human brain tumors on MR images using a long-circulating, superparamagnetic iron oxide agent
J Magn Reson Imaging. 1999;9:228-32 - PMID: 10077018
Hofmann, B, Bogdanov A Jr, Marecos E, Ebert W, Semmler W, Weissleder R
Mechanism of gadophrin-2 accumulation in tumor necrosis
J Magn Reson Imaging. 1999;9:336-41 - PMID: 10077034

Investigator

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