About

Brown, Dennis, PhD

Dennis_brown
Phone: 617-726-5665
Email: Brown.Dennis@mgh.harvard.edu
Lab: Brown

Research

Dennis Brown is a Ph. D. cell biologist who specializes in the use of state-of-the art fluorescence imaging and electron microscopy techniques to follow and dissect physiologically-relevant membrane protein trafficking events in epithelial and non-epithelial cells. He serves as the Associate Director of the CSB and the Director of the MGH Program in Membrane Biology (PMB) which uses use state of the art technologies in the pursuit of important biological questions at the system level. He became Professor of Medicine at Harvard in 2001 and has been at MGH since 1985.

Publications

Reiser J, Polu KR, Moller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
Nat Genet. 2005;37(7):739-44 - PMID: 15924139 - PMCID: PMC1360984
Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP
The B1-subunit of the H(+) ATPase is required for maximal urinary acidification.
P Natl Acad Sci U S A. 2005;102(38):13616-21 - PMID: 16174750 - PMCID: PMC1224669
Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S
Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling.
J Biol Chem. 2005;280(9):8452-63 - PMID: 15591047
Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D
Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra).
Am J Physiol-Renal. 2005;288(6):F1103-12 - PMID: 15644488
Bouley R, Hawthorn G, Russo L, Lin H, Ausiello D, Brown D
Aquaporin 2 (AQP2) and vasopressin receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in "endocytosis-resistant" membrane domains after vasopressin treatment.
Abdom Imaging. 2005;:ePub - PMID: 16104839

Investigator

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