Chemical Biology Platform
The chemical biology platform enables the use of chemical probes to understand biologic pathways and phenotype cellular states in health and disease. These probes may be directed at validated disease targets, or applied in a "forward genetic" approach that is systematic and less dependent on a priori assumptions. Platform activities encompass two interrelated efforts: 1) Synthetic chemistry, including the creation of novel small molecules, nanomaterials, and imaging probes; 2) High-throughput screening and analysis, utilizing a variety of biochemical, metabolic, and high-content imaging measurements.
Synthetic Chemistry
- Ralph Mazitschek, PhD
- Carlos Tassa, PhD
High-Throughput Screening and Analysis
- Stanley Shaw, MD PhD
- Ralph Weissleder, MD PhD