Physician researcher Ralph Weissleder serves as Director of the MGH Center for Systems Biology. He has been a driving force in the development of novel imaging tools and their application to understanding complex diseases. He has developed systematic ways to explore disease biology using library approaches and has been instrumental in translating several discoveries into new drugs.
Mikael Pittet , PhD, is Assistant Professor at Harvard Medical School and Assistant in Cell Biology at Massachusetts General Hospital. He studies network dynamics and regulation of T cell and monocyte responses in complex in vivo environments, and employs various three-dimensional bioimaging technologies to analyze cellular networks and their role in health and disease.
Sylvie Breton is a PhD in Biophysics who specializes in the cell biology of membrane transport, using a multidisciplinary approach including high-resolution laser scanning confocal microscopy, 3D reconstructions of single cells, and electrophysiological techniques. She studies luminal acidification, and water and solute transport in the male reproductive tract. She became Associate Professor of Medicine at Harvard Medical School and Assistant Biologist at the Massachusetts General Hospital in 2006, and she has been at MGH since 1994.
Dennis Brown is a Ph. D. cell biologist who specializes in the use of state-of-the art fluorescence imaging and electron microscopy techniques to follow and dissect physiologically-relevant membrane protein trafficking events in epithelial and non-epithelial cells. He serves as the Associate Director of the CSB and the Director of the MGH Program in Membrane Biology (PMB) which uses use state of the art technologies in the pursuit of important biological questions at the system level. He became Professor of Medicine at Harvard in 2001 and has been at MGH since 1985.
Stanley Shaw , MD PhD, is a cardiologist who uses systematic chemical biology and genomics approaches to discover underlying mechanisms and novel therapies for complex diseases. His research focuses on patient-derived cells, in order to understand the phenotypes of disease mutations in their native genetic context, and to modulate biologic pathways for therapeutic effect. He became one of the core faculty members in the Center for Systems Biology in 2007.
Herbert Y. Lin , MD PhD is a physician researcher who studies the role of the TGF-&beta/BMP signaling pathway in chronic diseases such as chronic kidney disease, hemochromatosis, and anemia of chronic disease. He uses a multidisciplinary approach including biochemistry, cell biology and animal studies. His research has generated novel therapeutic applications for the treatment of these disorders. He is an Associate Professor of Medicine at HMS and MGH since 2007.